Chapter 3. Tissue - Repair
Chapter 3. Tissue - Repair
Chapter Three
TISSUE REPAIR
left lobe
Liver
now
1 week enlarged
after
resection
LECTURE OVERVIEW
• By 24 hours:
• Endothelial cells start proliferating
• Fibroblasts emigrate
• By 3-5 days:
• granulation tissue present
• Weeks later:
• dense fibrosis (scar)
• scar is remodeled over time
SCARRING
Summary:
1. make granulation tissue
2. turn it into a chunk of collagen
Granulation tissue
Scar
LECTURE OVERVIEW
• First intention
• Second intention
SKIN WOUND HEALING
2 days
1 week
SKIN WOUND HEALING
• More inflammation
• More granulation tissue
• Wound contraction
Skin ulcer: large gap between edges
Skin ulcer: granulation tissue
Skin ulcer: re-epithelialization
SKIN WOUND HEALING
Wound Strength
• Extrinsic factors
– Infection
– Diabetes
– Steroids