Parasitic Infections

Parasites include,various protozoa
and worms which may infect

humans, causing parasitic diseases.
A parasitic infection is an infection

caused or transmitted by a parasite.
Many parasites do not cause diseases.
Parasitic infection can affect practically
al living organisms, including plants and
animals.
Symbiosis: Living together
Commensalism: One symbiont
benefits, other unaffected
Mutualism: Both symbionts benefit
Parasitism: One symbiont
benefits, other is damaged
Roundworms Each causes different
Tapeworms symptoms and different
Hook worms infections.
Heart worms
Amoeba
Flies, Fleas, Lice,
Mites , Ticks,
and Spiders.
Ingestion
Arthropoda bites
Penetration of intact skin
or mucous membranes
Figure 23.1
Some parasites must migrate to
certain locations within the host
in order to complete their life
cycle
Non-human parasites, in humans,
often fail to migrate properly
and become “dead-end infections”
------The relationship between two living
things (animals). Two living things live
together and involve protection or
other advantages to one or both
partner
------ An association which is beneficial to
both living things.
Lichen and fungus - lichen (plants lookalike or

algae) would survive with the fungus by
attaching itself on rock and absorbs in
nutrients. in return the lichen uses the nutrients
made by the fungus to produce carbon
dioxide so the fungus can photosynthesize.
------ Both partners are
able to lead
indepenent lives,
but one may gain
advantage from the
association when
they are together
and least not Fig. A female pea crab in the mantle
cavity of its mussel host. The crab
damage to the other. does not damage the mussel and
uses its shell purely for protection
------ An association which is beneficial to one
partner and harmful to the other partner.
The former that is beneficial to is called
parasite, the latter that is harmful to is
called host.
Human parasites are divided
into endoparasites, which
cause infection inside the body,
and ectoparasites, which
cause infection superficially
within the skin.
Endoparasites
1 Protozoan organisms
2 Helminths organisms (worms)
Tapeworms
Flukes
Roundworms
3 Other
organisms
Protozoa
Plasmodium spp. - causes Malaria

Entamoeba - causes amoebiasis, amoebic dysentery
Giardia - causes Giardiasis
Trypanosoma brucei - causes African sleeping sickness
Helminths organisms (worms)

Pinworm - causes Enterobiasis
Guinea Worm - also known as Dracunculiasis
Hookworm
Tapeworm
Bedbug
Head louse - Pediculosis
Bodylouse - Pediculosis
Scabies
Demodex - Demodicosis
Flea etc
CAUSES
MODE OF TRANSMISSION
INCUBATION PERIOD
LIFE CYCLE
SYMPTOMS
TREATMENT
ENTAMOEBA HYSTOLYTICA
 Causes amoebic dysentery
 About 50 million people worldwide
are affected
 Carried asymptomatically in the
digestive tracts of humans
 No animal reservoir exists
CAUSES :Infection occurs most often by
drinking water contaminated with feces
containing cysts; can be transmitted through
contaminated food.
MODE OF TRANSMISSION: Ingestion of

fecally contaminated water and food (raw
vegetables), by fecally contaminated hands of
foodhandlers
INCUBATION PERIOD: Variable, from a few

days to several months; usually 2-4 weeks
SYMPTOMS: Abdominal pain, diarrhea,
fatigue, fever, vomiting, bloody stool, weight
loss
TREATMENT: Susceptible to metronidazole,

tinidazone, ornidazole, deloxanide furoate,
chloroquine, tetracycline
 Found in intestinal tracts of animals and in the
environment
 Causative agent of giardiasis
Common gastrointestinal disease in the world.
Range from asymptomatic infection to
gastrointestinal
disease
The parasite multiplies in the small intestines
 Symptoms: diarrhea, abdominal cramps, vomiting,

fever Prevention: use of filtered water
Figure 23.8
TRANSMISSION :Giardia infection can occur
through ingestion of dormant microbial cysts in
contaminated water, food, or by the faecal-
oral route .
INCUBATION PERIOD: 1 to 3 weeks after

exposure to the parasite.
TREATMENT : Human infection is

conventionally treated
with metronidazole, tinidazole or nitazoxanide.
Although metronidazole is the current first-
line therapy.
Malaria
Plasmodium
 Causative agent of malaria
 Around 216 million cases of malaria worldwide; 1.2 million
deaths.(WHO 2012)
 Four species cause malaria
P. falciparum, P. vivax, P. ovale, and P. malariae
 Malaria is endemic throughout the tropics and subtropics
 Mosquitoes (Anapholes) are vector for Plasmodium
 The Plasmodium life cycle has three prominent stages
Plasmodium
 Some genetic traits increase malaria resistance in
endemic areas
Sickle-cell trait
Sickle-
shaped cells
resist
penetration
by
Plasmodium
Hemoglobin C
Two genes
for
hemoglobin
C protect
against
malaria
Malaria
 Symptoms of malaria depend on cycle of parasite:
 High fever, joint pain, vomiting, weakness, renal failure,
confusion, seizures
 Cerebral malaria results in tissue death in the brain (P.
falciparum)
 Immunity develops if victim survives acute stage

Periodic episodes become less severe over time
Treatment
- Various antimalarial medication
– type depends on severity of
case
Prevention
- Avoid getting bitten
- Use anti-malaria medication
(prophylaxis) –
chloroquine, mefloquine,
primaquine
Leishmania
 Causes leishmaniasis, transmitted by sand fly bites
 Endemic in parts of the tropics and subtropics
 Wild and domestic dogs and small rodents are common
hosts
2 million new cases yearly around the world
Symptoms:
* weight loss, low blood count, fever, dark
skin
pigmentation, renal failure, skin ulcers, etc.
Treatment – medication
Prevention – prevention of being
bitten
CAUSE: It is a parasitic disease of humans and
other animals, caused by protozoa of the
species Trypanosoma brucei and transmitted by
the tsetse fly.
SYMPTOMS: Characterized by fever, headaches,
joint pains, and itching.Invasion of the circulatory
and lymphatic systems by the parasites is
associated with severe swelling of lymph nodes.
Disruption of the sleep cycle is a leading
symptom of this stage and is the one that gave
the disease the name 'sleeping sickness.'
TREATMENT: Currently there are few medically related
prevention options for Trypanosomiasis (i.e. no
vaccine exists for immunity). Although the risk of
infection from a tsetse fly bite is minor (estimated at
less than 0.1%), the use of insect repellants, wearing
long-sleeved clothing, avoiding tsetse-dense areas are
best preventing option.
Helminths are macroscopic, multicellular,
eukaryotic worms
Life cycles are complex
Intermediate hosts are often needed to support
larval stages
Three groups of helminthes
Cestodes (tapeworm)
Trematodes (fluke)
Nematodes (roundworm)
Tapeworm Infestation is the infection of the digestive
tract by adult parasitic flatworms called cestodes
or tapeworms. Live tapeworm larvae are sometimes
ingested by consuming undercooked food. Once inside
the digestive tract, a larva can grow into a very large adult
tapeworm.
Mode of Infection: Most common tapeworms in
humans are the pork tapeworm (T. solium),
the beef tapeworm (T. saginata), the fish
tapeworm and the dwarf tapeworm
Incubation period: It takes about 5 to 12 weeks

for the worm to mature into adulthood in the
human intestine
SYMPTOMS:
Although tapeworms in the intestine usually cause no
symptoms, some people experience upper abdominal
discomfort, diarrhea, and loss of appetite. Anemia
may develop in people with the fish tapeworm.
Infection is generally recognized when the infected
person passes segments of proglottids in the stool
(looks like white worms), especially if a segment is
moving.
Rarely, worms may cause obstruction of the intestine.

And very rarely, T. solium larvae can migrate to the
brain causing severe headaches, seizures and other
neurological problems. This condition is
called neurocysticercosis. It can take years of
development before the patient has those symptoms of
the brain.
Tapeworms are treated with medications taken
by mouth, usually in a single dose. The drug
of choice for tapeworm infections is
praziquantel.
Niclosamide can also be used.
Ascariasis is a disease of humans caused by
the parasitic roundworm Ascaris lumbricoides.
CAUSE : Infection occurs by swallowing food

contaminated with Ascaris eggs from feces.
The larvae hatch in the intestine, burrow
through the gut wall, and migrate to
the lungs through the blood system.
MODE OF TRANSMISSION: The source of transmission
is from soil and vegetation on which fecal matter
containing eggs has been deposited. Ingestion of infective
eggs from soil contaminated with human feces or
transmission and contaminated vegetables and water is
the primary route of infection.
INCUBATION PERIOD: 4-8 weeks
SYMPTOMS :As larval stages travel through the
body, they may cause visceral
damage, peritonitis and inflammation, enlargement of
the liver or spleen, and a verminous pneumonitis. The
worms in the may cause
malabsorption intestine and which
to anorexia contribute
malnutrition
Prevention : Use of toilet facilities; safe excreta
disposal; protection of food from dirt and soil;
thorough washing of produce; and hand
washing. Food dropped on the floor should
never be eaten without washing or cooking,
particularly in endemic areas. Fruits and
vegetables should always be washed
thoroughly before consumption.
Treatment: Mebendazole, Albendazole,

Piperazine etc.
It is a parasitic filarial nematode (roundworm)
spread by a mosquito vector. It cause
lymphatic filariasis, an infection of the
lymphatic system by filarial worms.
INCUBATION PERIOD: The incubation period
is variable and often difficult to determine. Both
microfilaria and adult worms have been
observed in patients as early as 6 months and
as late as 12 months after infection
If the infection is left untreated, it can develop
into a chronic disease called elephantiasis.
Limited treatment modalities exist
and no vaccines have been
developed.
TREATMENT : The severe symptoms caused
by the parasite can be avoided by cleansing
the skin, surgery, or the use of therapeutic
drugs, such
as diethylcarbamazine (DEC), ivermectin,
or albendazole. The drug of choice, however, is
diethylcarbamazine.
It is the parasitic infestation of the body of a
live mammal by fly larvae (maggots) that grow
inside the host while feeding on its tissue.
MODE OF TRANSMISSION:There are three
main fly families causing economically
important myiasis in livestock and also,
occasionally in humans:
Calliphoridae (blowflies)
Oestridae (botflies)
Sarcophagidae (fleshflies)
SYMPTOMS: Myiasis varies widely in the
forms it takes and its effects on the victims.
Such variations depend largely on the fly
species and where the larvae are located.
Some flies lay eggs in open wounds, other
larvae may invade unbroken skin or enter the
body through the nose or ears, and still others
may be swallowed if the eggs are deposited on
the lips or on food
First response to cutaneous myiasis once the
breathing hole has formed, is to cover the air
hole thickly with petroleum jelly. Lack of oxygen
then forces the larva to the surface, where it
can more easily be dealt with. In a clinical or
veterinary setting there may not be time for
such tentative approaches, and the treatment
of choice might be more direct, with or without
an incision. First the larva must be eliminated
through pressure around the lesion and the use
of forceps. Secondly the wound must be
cleaned and disinfected.

Parasitic Infections

Uploaded by

Copyright:

Available Formats

Parasitic Infections

Uploaded by

Document Information

Original Description:

Original Title

Copyright

Available Formats

Share this document

Share or Embed Document

Sharing Options

Did you find this document useful?

Is this content inappropriate?

Copyright:

Available Formats

Parasitic Infections

Uploaded by

Copyright:

Available Formats

Parasites include,various protozoa

and worms which may infect

A parasitic infection is an infection

Lichen and fungus - lichen (plants lookalike or

Plasmodium spp. - causes Malaria

Helminths organisms (worms)

MODE OF TRANSMISSION: Ingestion of

INCUBATION PERIOD: Variable, from a few

TREATMENT: Susceptible to metronidazole,

 Symptoms: diarrhea, abdominal cramps, vomiting,

INCUBATION PERIOD: 1 to 3 weeks after

TREATMENT : Human infection is

 Immunity develops if victim survives acute stage

Incubation period: It takes about 5 to 12 weeks

Rarely, worms may cause obstruction of the intestine.

CAUSE : Infection occurs by swallowing food

Treatment: Mebendazole, Albendazole,

You might also like