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Edible Vaccines: DR Fatima Shad K Professor Panjwani Center For Molecular Medicine and Drug Research
Edible Vaccines: DR Fatima Shad K Professor Panjwani Center For Molecular Medicine and Drug Research
Dr Fatima Shad K Professor Panjwani Center For Molecular Medicine and Drug Research
Opening a new era in vaccine delivery, researchers supported by the National Institute of Allergy and Infectious Diseases (NIAID) have shown for the first time that an edible vaccine can safely trigger significant immune responses in people.
Immune responses to vaccines are influenced by: 1. the route of immunization (injection or oral), 2. the form of the antigen (live, killed, soluble, peptide subunit, particulate, etc.) and 3. the presence in the vaccine of biologically active elements that mediate specific tissue tropisms. They may also contain adjuvants, vectors or vehicles (Walker, 1994; Spriggs, 1996) that effect the quality and quantity of immune response.
A lot to swallow
WONDERS OF MUCOUS
Pathogen enters through orifices First line of defense in the mucous lining of these openings GIT Reproductive System Respiratory System Urinary System
"Edible vaccines offer exciting possibilities for significantly reducing the burden of diseases like hepatitis and diarrhea, particularly in the developing world where storing and administering vaccines are often major problems," says Anthony S. Fauci, M.D., director of NIAID.
Immune System
Recognize pathogens through antigens Viruses should be attenuated Good to eat raw edible vaccines Tomato, Potato, Rice, Tobacco and banana are good candidates for edible vaccines Hepatitis B and Cholera How to avoid degeneration of antigen in stomach? Why weaker virus causes immunity NOT disease? Why we cannot cook them? Why banana is an ideal vector for vaccine? How Hepatitis B virus travels through the body?