If you keep up with skincare trends at all, you know about the rising popularity of glutathione. Celebrities like Kendall Jenner and Hailey Bieber are known to receive regular antioxidant IV infusions with glutathione to rejuvenate their skin. But what exactly does it do? It is reputed to protect the skin against free radicals and aid in cellular repair. To understand the benefits and mechanisms of this ingredient better, we spoke to the experts. Here’s what they had to say
What is glutathione?
Glutathione is a natural antioxidant that our bodies produce in the liver using three amino acids: glycine, cysteine, and glutamic acid. You can boost your glutathione levels by eating foods like avocados, apples, peaches, asparagus, and spinach.
How does glutathione work?
Our bodies naturally produce glutathione and is the most powerful antioxidant we have. This compound, made from three amino acids, protects us from free radicals and oxidative stress, which contribute to premature ageing and many diseases. In short, it acts as a natural shield and a pro-longevity substance. However, like collagen, our glutathione levels decrease with age, making supplementation essential. But which supplement should you choose? Shabir Daya, pharmacist and co-founder of Victoria Health breaks it down for us.
What is glutathione good for?
Glutathione plays a crucial role in protecting cells from damage caused by free radicals, which are produced during the process of energy creation and cellular repair, explains Shabir Daya. “Among the many antioxidants in our bodies, glutathione stands out as the most powerful electron donor, effectively neutralising harmful free radicals and preventing oxidative stress,” says Daya. Oxidative stress occurs when there is an insufficient amount of antioxidants, leading to damage to our genetic material and organs. A deficiency in glutathione can increase the risk of various diseases.
Benefits of glutathione:
- Counteracts oxidative stress in cells and the action of free radicals.
- Protects cells in the hippocampus, the portion of the brain responsible for memory and learning, from oxidative stress, and may help prevent neurodegenerative diseases.
- Strengthens the immune system, supporting the action of white blood cells that fight viruses and bacteria.
- Helps detoxify the liver and protects it from diseases such as hepatic steatosis, the so-called "fatty liver".
- Protects against damage to RPE cells in the eye and helps prevent age-related macular degeneration.
- Due to its powerful antioxidant and anti-inflammatory properties, it is beneficial for skin health, and helps prevent wrinkles and skin laxity.
Does glutathione make you lose weight?
Research published in National Library of Medecine found that proper levels of glutathione in the body can help you lose weight more easily because it supports the body in burning fat and building muscle mass while supporting the liver in removing toxins and eliminating them.
Side effects of glutathione
There are no contraindications or side effects to taking glutathione in supplement form. It is reported that it may cause gastrointestinal upset in some cases.
Who should take glutathione? Can it benefit everyone?
Almost everyone can benefit from taking glutathione supplements, especially as we age since our bodies produce less of it along with other essential compounds and hormones. “If you experience stress, have a compromised immune system, live in highly polluted cities, or suffer from chronic inflammatory diseases, glutathione supplementation can be particularly advantageous,” adds Daya.
Are all glutathione supplements the same? Which ones should we choose?
The fastest and most direct way to take glutathione is through infusion therapy. Alternatively, high-quality supplements can also be effective. "Glutathione exists in two states: the oxidised state and the reduced state, known as GSH," explains Shabir Daya. "It is the GSH state that is needed to neutralise free radicals and protect the body from various toxins. In addition to preferring the reduced GSH version of glutathione, it is advisable to use the liposomal version, where glutathione is encapsulated in liposomes. These lipids protect it from stomach acids, ensuring it arrives intact in the gut for optimal absorption. GSH glutathione can then enter cells and neutralize harmful free radicals," he adds.
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