Fudosteine

Fudosteine
Clinical data
Trade names	Cleanal
Other names	S-(3-Hydroxypropyl)-L-cysteine
Legal status
Legal status	Rx in Japan;
Identifiers
	IUPAC name (2R)-2-Amino-3-(3-hydroxypropylsulfanyl)propanoic acid;
CAS Number	13189-98-5;
PubChem CID	134669;
ChemSpider	118692;
UNII	UR9VPI71PT;
KEGG	D01845;
ChEBI	CHEBI:31637;
ChEMBL	ChEMBL1555183;
CompTox Dashboard (EPA)	DTXSID4046440 ;
Chemical and physical data
Formula	C6H13NO3S
Molar mass	179.23 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C(CO)CSC[C@@H](C(=O)O)N;
	InChI InChI=1S/C6H13NO3S/c7-5(6(9)10)4-11-3-1-2-8/h5,8H,1-4,7H2,(H,9,10)/t5-/m0/s1; Key:KINWYTAUPKOPCQ-YFKPBYRVSA-N;

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Fudosteine (Cleanal) is a mucolytic agent.^[1] In Japan, it is approved for the treatment of bronchial asthma, chronic bronchitis, pulmonary emphysema, bronchiectasis, pulmonary tuberculosis, pneumoconiosis, atypical mycobacterial disease, and diffuse panbronchiolitis.^[2]

Fudosteine works by increasing mucin secretion by inhibiting expression of the protein mucin 5AC.^[3]

References

^ Rhee CK, Kang CM, You MB, Yoon HK, Kim YK, Kim KH, et al. (November 2008). "Effect of fudosteine on mucin production". The European Respiratory Journal. 32 (5): 1195–1202. doi:10.1183/09031936.00018508. PMID 18579549.
^ "Fudosteine". Inxight Drugs. National Center for Advancing Translational Sciences (NCATS), U.S. National Institutes of Health.
^ Antonela Antoniu S (January 2009). "Fudosteine effects on mucin production". Expert Opinion on Investigational Drugs. 18 (1): 105–107. doi:10.1517/13543780802623863. PMID 19053887. S2CID 219294005.

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[1] Rhee CK, Kang CM, You MB, Yoon HK, Kim YK, Kim KH, et al. (November 2008). "Effect of fudosteine on mucin production". The European Respiratory Journal. 32 (5): 1195–1202. doi:10.1183/09031936.00018508. PMID 18579549.

[2] "Fudosteine". Inxight Drugs. National Center for Advancing Translational Sciences (NCATS), U.S. National Institutes of Health.

[3] Antonela Antoniu S (January 2009). "Fudosteine effects on mucin production". Expert Opinion on Investigational Drugs. 18 (1): 105–107. doi:10.1517/13543780802623863. PMID 19053887. S2CID 219294005.

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