Jump to content

Fudosteine

From Wikipedia, the free encyclopedia

Fudosteine
Clinical data
Trade namesCleanal
Other namesS-(3-Hydroxypropyl)-L-cysteine
Legal status
Legal status
  • Rx in Japan
Identifiers
  • (2R)-2-Amino-3-(3-hydroxypropylsulfanyl)propanoic acid
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC6H13NO3S
Molar mass179.23 g·mol−1
3D model (JSmol)
  • C(CO)CSC[C@@H](C(=O)O)N
  • InChI=1S/C6H13NO3S/c7-5(6(9)10)4-11-3-1-2-8/h5,8H,1-4,7H2,(H,9,10)/t5-/m0/s1
  • Key:KINWYTAUPKOPCQ-YFKPBYRVSA-N

Fudosteine (Cleanal) is a mucolytic agent.[1] In Japan, it is approved for the treatment of bronchial asthma, chronic bronchitis, pulmonary emphysema, bronchiectasis, pulmonary tuberculosis, pneumoconiosis, atypical mycobacterial disease, and diffuse panbronchiolitis.[2]

Fudosteine works by increasing mucin secretion by inhibiting expression of the protein mucin 5AC.[3]

References

[edit]
  1. ^ Rhee CK, Kang CM, You MB, Yoon HK, Kim YK, Kim KH, et al. (November 2008). "Effect of fudosteine on mucin production". The European Respiratory Journal. 32 (5): 1195–1202. doi:10.1183/09031936.00018508. PMID 18579549.
  2. ^ "Fudosteine". Inxight Drugs. National Center for Advancing Translational Sciences (NCATS), U.S. National Institutes of Health.
  3. ^ Antonela Antoniu S (January 2009). "Fudosteine effects on mucin production". Expert Opinion on Investigational Drugs. 18 (1): 105–107. doi:10.1517/13543780802623863. PMID 19053887. S2CID 219294005.