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ADAM18

From Wikipedia, the free encyclopedia
ADAM18
Identifiers
AliasesADAM18, ADAM27, tMDCIII, ADAM metallopeptidase domain 18
External IDsMGI: 105986; HomoloGene: 74941; GeneCards: ADAM18; OMA:ADAM18 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001190956
NM_014237
NM_001320313

NM_010084

RefSeq (protein)

NP_001177885
NP_001307242
NP_055052

NP_034214

Location (UCSC)Chr 8: 39.58 – 39.73 MbChr 8: 25.09 – 25.16 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Disintegrin and metalloproteinase domain-containing protein 18 is an enzyme that in humans is encoded by the ADAM18 gene.[5][6]

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene is a sperm surface protein.[6]

References

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  1. ^ a b c ENSG00000278548 GRCh38: Ensembl release 89: ENSG00000168619, ENSG00000278548Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031552Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Frayne J, Hurd EA, Hall L (Aug 2002). "Human tMDC III: a sperm protein with a potential role in oocyte recognition". Mol Hum Reprod. 8 (9): 817–22. doi:10.1093/molehr/8.9.817. PMID 12200459.
  6. ^ a b "Entrez Gene: ADAM18 ADAM metallopeptidase domain 18".

Further reading

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