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Citrullinase

From Wikipedia, the free encyclopedia
citrullinase
Identifiers
EC no.3.5.1.20
CAS no.59088-17-4
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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PMCarticles
PubMedarticles
NCBIproteins

In enzymology, a citrullinase (EC 3.5.1.20) is an enzyme that catalyzes the chemical reaction

L-citrulline + H2O L-ornithine + CO2 + NH3

Thus, the two substrates of this enzyme are L-citrulline and H2O, whereas its 3 products are L-ornithine, CO2, and NH3.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is L-citrulline N5-carbamoyldihydrolase. Other names in common use include citrulline ureidase, citrulline hydrolase, and L-citrulline 5-N-carbamoyldihydrolase.

References

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  • Hill DL, Chambers P (1967). "The biosynthesis of proline by Tetrahymena pyriformis". Biochim. Biophys. Acta. 148 (2): 435–47. doi:10.1016/0304-4165(67)90140-7. PMID 6075416.