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TIRAP

From Wikipedia, the free encyclopedia
TIRAP
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesTIRAP, BACTS1, Mal, MyD88-2, wyatt, toll-interleukin 1 receptor (TIR) domain containing adaptor protein, TIR domain containing adaptor protein
External IDsOMIM: 606252; MGI: 2152213; HomoloGene: 14285; GeneCards: TIRAP; OMA:TIRAP - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001039661
NM_052887
NM_148910
NM_001318776
NM_001318777

NM_001177845
NM_001177846
NM_001177847
NM_054096

RefSeq (protein)

NP_001034750
NP_001305705
NP_001305706
NP_683708

NP_001171316
NP_001171317
NP_001171318
NP_473437

Location (UCSC)Chr 11: 126.28 – 126.3 MbChr 9: 35.1 – 35.11 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

TIRAP (TIR domain containing adaptor protein) is an adapter molecule associated with toll-like receptors. The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described.

Signaling pathway of toll-like receptors. Dashed grey lines represent unknown associations

See also

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000150455Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032041Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.