This report evaluates submissions received in response to a Request for Proposals (RFP) for Biomolecular Simulation Time on Anton 2, a supercomputer designed and built by D. E. Shaw Research (DESRES). Over the past 11 years, DESRES has made an Anton or Anton 2 system housed at the Pittsburgh Supercomputing Center available to the non-commercial research community, based on the advice of previous committees of the National Academies of Sciences, Engineering, and Medicine. The goal of the twelfth RFP for simulation time on Anton 2 is to continue to facilitate breakthrough research in the study of biomolecular systems by providing a massively parallel system specially designed for molecular dynamics simulations. These capabilities allow multi-microsecond simulation timescales. The program seeks to continue to support research that addresses important and high impact questions demonstrating a clear need for Anton's special capabilities.
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