GB2435426A - Wound healing system and dressing containing a dried form of a liquid - Google Patents
Wound healing system and dressing containing a dried form of a liquid Download PDFInfo
- Publication number
- GB2435426A GB2435426A GB0603630A GB0603630A GB2435426A GB 2435426 A GB2435426 A GB 2435426A GB 0603630 A GB0603630 A GB 0603630A GB 0603630 A GB0603630 A GB 0603630A GB 2435426 A GB2435426 A GB 2435426A
- Authority
- GB
- United Kingdom
- Prior art keywords
- active
- wound dressing
- layer
- ingredient
- liquid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 239000007788 liquid Substances 0.000 title claims abstract description 65
- 230000029663 wound healing Effects 0.000 title claims abstract description 14
- 208000027418 Wounds and injury Diseases 0.000 claims abstract description 96
- 206010052428 Wound Diseases 0.000 claims abstract description 95
- 239000000463 material Substances 0.000 claims abstract description 38
- 235000012907 honey Nutrition 0.000 claims abstract description 19
- 230000001464 adherent effect Effects 0.000 claims abstract description 11
- 235000010443 alginic acid Nutrition 0.000 claims abstract description 11
- 229920000615 alginic acid Polymers 0.000 claims abstract description 11
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims abstract description 10
- 229940072056 alginate Drugs 0.000 claims abstract description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 10
- 239000005871 repellent Substances 0.000 claims abstract description 9
- 230000002940 repellent Effects 0.000 claims abstract description 7
- 239000000341 volatile oil Substances 0.000 claims abstract description 7
- 229920001661 Chitosan Polymers 0.000 claims abstract description 5
- 229920001277 pectin Polymers 0.000 claims abstract description 5
- 239000001814 pectin Substances 0.000 claims abstract description 5
- 235000010987 pectin Nutrition 0.000 claims abstract description 5
- 239000012676 herbal extract Substances 0.000 claims abstract 6
- 239000001768 carboxy methyl cellulose Substances 0.000 claims abstract 4
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims abstract 4
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims abstract 4
- 229940105329 carboxymethylcellulose Drugs 0.000 claims abstract 4
- 239000004615 ingredient Substances 0.000 claims description 50
- 239000000843 powder Substances 0.000 claims description 34
- 239000000853 adhesive Substances 0.000 claims description 13
- 210000000416 exudates and transudate Anatomy 0.000 claims description 13
- 230000001070 adhesive effect Effects 0.000 claims description 12
- 239000012876 carrier material Substances 0.000 claims description 11
- 229920000728 polyester Polymers 0.000 claims description 11
- 230000000844 anti-bacterial effect Effects 0.000 claims description 9
- 238000010276 construction Methods 0.000 claims description 5
- NBVXSUQYWXRMNV-UHFFFAOYSA-N fluoromethane Chemical compound FC NBVXSUQYWXRMNV-UHFFFAOYSA-N 0.000 claims description 3
- 229920006264 polyurethane film Polymers 0.000 claims description 2
- 229940045110 chitosan Drugs 0.000 abstract 1
- 229960000292 pectin Drugs 0.000 abstract 1
- 238000000034 method Methods 0.000 description 21
- 239000000047 product Substances 0.000 description 20
- 239000010410 layer Substances 0.000 description 16
- 230000008569 process Effects 0.000 description 16
- 238000000576 coating method Methods 0.000 description 15
- 239000011248 coating agent Substances 0.000 description 12
- 230000035876 healing Effects 0.000 description 10
- 238000001035 drying Methods 0.000 description 9
- 240000003553 Leptospermum scoparium Species 0.000 description 8
- 235000016887 Leptospermum scoparium Nutrition 0.000 description 8
- 239000000203 mixture Substances 0.000 description 8
- 239000002274 desiccant Substances 0.000 description 7
- 230000008901 benefit Effects 0.000 description 6
- 238000010030 laminating Methods 0.000 description 6
- 239000002245 particle Substances 0.000 description 6
- 239000000758 substrate Substances 0.000 description 6
- 230000009286 beneficial effect Effects 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 5
- 229940127554 medical product Drugs 0.000 description 5
- 229920000297 Rayon Polymers 0.000 description 4
- 238000011282 treatment Methods 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 3
- 244000146462 Centella asiatica Species 0.000 description 2
- 235000004032 Centella asiatica Nutrition 0.000 description 2
- 206010053567 Coagulopathies Diseases 0.000 description 2
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 2
- 230000002745 absorbent Effects 0.000 description 2
- 239000002250 absorbent Substances 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 239000011149 active material Substances 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 230000001680 brushing effect Effects 0.000 description 2
- 238000009960 carding Methods 0.000 description 2
- 239000011247 coating layer Substances 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 239000000835 fiber Substances 0.000 description 2
- 239000012467 final product Substances 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 238000003475 lamination Methods 0.000 description 2
- 230000014759 maintenance of location Effects 0.000 description 2
- 238000002844 melting Methods 0.000 description 2
- 230000008018 melting Effects 0.000 description 2
- 229910052709 silver Inorganic materials 0.000 description 2
- 239000004332 silver Substances 0.000 description 2
- 230000017423 tissue regeneration Effects 0.000 description 2
- MSWZFWKMSRAUBD-IVMDWMLBSA-N 2-amino-2-deoxy-D-glucopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-IVMDWMLBSA-N 0.000 description 1
- AJBZENLMTKDAEK-UHFFFAOYSA-N 3a,5a,5b,8,8,11a-hexamethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysene-4,9-diol Chemical compound CC12CCC(O)C(C)(C)C1CCC(C1(C)CC3O)(C)C2CCC1C1C3(C)CCC1C(=C)C AJBZENLMTKDAEK-UHFFFAOYSA-N 0.000 description 1
- 241000049213 Aloe gariepensis Species 0.000 description 1
- 244000099147 Ananas comosus Species 0.000 description 1
- 235000007119 Ananas comosus Nutrition 0.000 description 1
- 240000004178 Anthoxanthum odoratum Species 0.000 description 1
- 108010004032 Bromelains Proteins 0.000 description 1
- 235000003880 Calendula Nutrition 0.000 description 1
- 240000001432 Calendula officinalis Species 0.000 description 1
- 235000007866 Chamaemelum nobile Nutrition 0.000 description 1
- 244000133098 Echinacea angustifolia Species 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 244000166124 Eucalyptus globulus Species 0.000 description 1
- 240000001238 Gaultheria procumbens Species 0.000 description 1
- 235000007297 Gaultheria procumbens Nutrition 0.000 description 1
- 241000208680 Hamamelis mollis Species 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 1
- 244000178870 Lavandula angustifolia Species 0.000 description 1
- 235000010663 Lavandula angustifolia Nutrition 0.000 description 1
- 244000042664 Matricaria chamomilla Species 0.000 description 1
- 235000007232 Matricaria chamomilla Nutrition 0.000 description 1
- 239000004952 Polyamide Substances 0.000 description 1
- -1 Polyethylene Polymers 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 241001256311 Selenis Species 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 240000002299 Symphytum officinale Species 0.000 description 1
- 235000005865 Symphytum officinale Nutrition 0.000 description 1
- 239000004809 Teflon Substances 0.000 description 1
- 229920006362 Teflon® Polymers 0.000 description 1
- 208000000558 Varicose Ulcer Diseases 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 239000012790 adhesive layer Substances 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 description 1
- 239000003139 biocide Substances 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 235000019835 bromelain Nutrition 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000035602 clotting Effects 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 235000014134 echinacea Nutrition 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 210000002919 epithelial cell Anatomy 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 229960002442 glucosamine Drugs 0.000 description 1
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 1
- 235000004554 glutamine Nutrition 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000000025 haemostatic effect Effects 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 239000001102 lavandula vera Substances 0.000 description 1
- 235000018219 lavender Nutrition 0.000 description 1
- 239000011344 liquid material Substances 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 230000035800 maturation Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 235000003170 nutritional factors Nutrition 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 230000000472 traumatic effect Effects 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 229940118846 witch hazel Drugs 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 235000016804 zinc Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/40—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof, e.g. plant or animal extracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Botany (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Materials For Medical Uses (AREA)
Abstract
A wound healing system and dressing comprise a layer of a dried liquid <B>3.</B> The dried liquid may be dried honey, dried essential oils or dried herbal extracts. The dried liquid may be combined with an alginate, chitosan, carboxy-methyl cellulose or pectin. The dried liquid may be coated onto a non-woven base material 4. The dressing may incorporate a low adherent contact surface <B>2</B> and/or a water repellent film 6 on a side opposing a wound <B>1</B>.
Description
<p>I</p>
<p>Medical Wound Healing Treatment</p>
<p>Field of the Invention</p>
<p>The present invention relates to Systems and Products to provide a Medical Wound Healing Treatment, particularly, though not exclusively, to dressings and to nonwoven materials for use in such products.</p>
<p>Background to the Invention</p>
<p>Wounds are dressed for many reasons including: * To stop blood flow and prevent exudate soiling * To protect the wound from further damage * To prevent contamination and infection * To provide conditions for healing Wound healing is a natural process that occurs after any injury, either traumatic or elective and there are four recognised phases of the healing process: 1. Inflammation -Clotting 2. Migration - Epithelial Cells replace lost tissue 3. Proliferation -Granulation and closure 4. Maturation -Strengthening of new skin These phases take place sequentially and timing is dependent on a number of variables.</p>
<p>The healing process may vary due to internal or external conditions at the healing site, for example moisture content, oxygen levels, bacterial presence, blood flow and so on.</p>
<p>It is now firmly established that optimal wound healing takes place under moist conditions so provision and retention of moist conditions at the wound healing site is beneficial.</p>
<p>Every wound is different, but it is accepted that improvements in the speed and/or quality of the wound healing process are beneficial.</p>
<p>These benefits may be, for example cosmetic, earlier release from hospital (bed release and cost reduction), early return to work or patient quality of life for difficult to heal' wounds such venous ulcers.</p>
<p>In order to facilitate the wound healing process various treatments are available which can provide ways to accelerate the healing process by using a so called Active' ingredient, for</p>
<p>example:</p>
<p>* Haemostats to provide additional or controlled clotting * Biocides to reduce or eliminate potential infection * Humectants or Gels to provide or maintain a moist healing site * Enzymes to provide enzymatic activity at the healing site Usually the Active' treatment application is applied directly to the wound as soon as possible after the wound has been made, for example a simple First Aid dressing or a Post Operative Surgical Dressing, and is replaced when needed.</p>
<p>Recently there has also been a revised interest io called Natural' active materials for wound healing.</p>
<p>These Natural' materials include for example: * Honey (especially Manuka honey) * Herbs (e.g. Aloe Vera, Gotu kola, Chamomile, Calendula, Echinacea, Comfrey) * So called Essential oils' occurring in plants and responsible for their properties (e.g. Tea Tree, Lavender, Eucalyptus, Witch hazel, Wintergreen) Researchers are continuing to explore the complex dynamics of tissue repair and are finding that nutritional factors are involved in tissue regeneration, including Vitamins A, C and E, zinc, Glutamine and Glucosamine.</p>
<p>They are finding that botanical extracts from Aloe Vera, Centella asiatica and bromelain from pineapple, can improve healing time and wound outcome.</p>
<p>However one disadvantage of these Natural' materials and other potentially useful active ingredients, is that they are often only available in liquid form.</p>
<p>This means that they have to be applied to the wound site in liquid form (e.g. as an oil, lotion, cream etc.) and the covered with a protective wound dressing.</p>
<p>This is far less controllable, less convenient, more time consuming and normally more expensive than being able to apply a dry Active' wound dressing with a controlled amount of the active material already built in.</p>
<p>However an advantage of the liquid Active' materials is that they are compatible with the provision, retention and benefits of a moist healing environment.</p>
<p>Accordingly the present invention aims to retain the benefits whilst addressing at least one disadvantage associated with the prior art whether discussed herein or otherwise.</p>
<p>Summary of the Invention</p>
<p>To overcome this problem of the prior art, this invention proposes a system, which can provide a method of producing a wound dressing product using a liquid Active' material, by converting the liquid Active' material to a Dry' form.</p>
<p>This Dry' form of the Active liquid can then be handled by conventional machinery used for processing dry Active' materials to produce an Active' wound dressing material and a wound dressing product from this material.</p>
<p>The process for converting the liquid Active' material into a suitable dried form is used extensively in the Food Industry and is one of several methods mentioned below.</p>
<p>Four methods are typically used within the food industry to dry liquid materials, in order to make them usable in a Dry' form: * Freeze drying; * Vacuum belt drying; * Roller drying; * Spray drying.</p>
<p>In the Vacuum belt method the product is fed into the drying system in liquid or solid form. The water is evaporated under a vacuum to depress the boiling point. The advantage of this process is that thick or lumpy products can he dried.</p>
<p>These processes will be well known to those experienced in this area.</p>
<p>In addition to these basic drying processes special so-called drying agents' can be added to the liquid to be dried in order to speed up or remove more moisture during the drying process.</p>
<p>These drying' agents are often in the form of a dry powder additive.</p>
<p>We have found that some powders, with properties that can help the wound healing process (so-called Active ingredient' powders), can also act as a drying agent'.</p>
<p>By combining an Active powder' as part or all of the drying agent' with an Active liquid' the healing properties can be further increased.</p>
<p>A variety of Active powders' can be used, for example alginates, chitosans, carboxy -methy cellulose, pectins etc. For example, an Active' alginate powder can be used as part of the drying agent' with a sticky' liquid such as honey. In this way the moisture retaining and haemostatic properties of the Active' alginate powder can be combined with the anti-microbial properties of the dried liquid honey (particularly Manuka honey) in a dry form which can be applied as a coating layer to a suitable base, carrier material for use in a wound dressing..</p>
<p>A further benefit of combining an Active' liquid with an Active' powder is that current application of Active' dry materials can be dusty, leading to variations in weight application as well as contaminating process machinery and any other items in close proximity.</p>
<p>Thereby combination is mutually beneficial.</p>
<p>The dried Active' material is then used in a conventional coating process to apply an Active' layer to a suitable wound dressing base, carrier material.</p>
<p>This, for example, can be done by mixing the dried Active' material with a suitable thermo-sensitive fusible powder (e.g. Polyethylene, Polyamide), scatter coating the required weight onto the base, carrier material. Alternatively, the coating powder could be incorporated into the drying process together with the drying agent'.</p>
<p>The coated product is then passed through a laminator where it is carried between two non-stick belts (usually Teflon coated) through a heated zone in order to melt the fusible powder. By varying the belt gap and the pressure applied to the belt, the coating and base material are pressed together to form an adequately bonded Active' layer.</p>
<p>Alternatively the coated product is passed under Infra Red heaters to melt the fusible powder and then through water cooled rollers under pressure to press the coating and the base material together to form an adequately bonded Active' layer.</p>
<p>The methods described for the application of the coating layer and the production of base, carrier materials will be well know to those experienced in these areas.</p>
<p>This coated material can then be converted into a wound dressing product using conventional dressing conversion machinery since it is in a Dry' rather than a Wet' form.</p>
<p>The final product may be loose' for application under a bandage or a self-adhesive system, for example a so-called Island' dressing.</p>
<p>The final product may incorporate a low adherent wound contact layer and/or a liquid impervious, breathable outer membrane.</p>
<p>The product is constructed so that the required Active' ingredient is included in the layer closest to the wound surface, ne Active' ingredients are selected so that on ntact with the exudate from the wound or by intervention (e.g. application of water or saline solution), they provide the required Active' effect The construction of the structure is provided to allow for passage of liquids so that wound exudate or other liquid may more easily contact the Active' ingredient.</p>
<p>This passage of liquids can also be provided by what is normally called absorbency and is a well known feature of wound dressings.</p>
<p>The medical product may comprise the layered structure containing the Active' ingredients and a net, perforated film or gauze on one or both sides thereof.</p>
<p>The medical product may comprise a low adherent wound contact net or perforated film, known per se for use in wound dressings, bonded to at least one side of the layered structure said side to he a wound contact side. The net or perforated film thus provides a wound contact layer having apertures to allow wound fluids to pass into the Active' layered structure of the dressing.</p>
<p>The net may comprise a low adherent bi-extruded net where one of the bi-extruded layers acts as a fusible adhesive and can be heat bonded to the Active' layered structure.</p>
<p>The medical product may comprise the Active' layered structure having a film or water repellent layer, known per se for use in wound dressings, on one side thereof The said film or water repellent layer is provided on a side of the product opposed to the wound contacting side and may assist in providing a moist wound environment and/or assist to reduce the rate of wound exudate strike through.</p>
<p>Suitably the medical product comprises a polyurethane film bonded to one side of the Active' layered structure.</p>
<p>The medical product is arranged to be used for wound care and/or padding bandage applications.</p>
<p>Brief description of the Drawings</p>
<p>Figure 1 shows a cross section through a multi-layer wound dressing incorporating the elements of the invention.</p>
<p>Not all the elements are needed in a wound dressing product and this drawing shows several elements for illustration only.</p>
<p>Figure 1 shows: 1. The Wound 2. A low adherent wound contact layer, which in use is in contact with the wound.</p>
<p>3. The Active' layer as described in the Summary of the Invention, Examples and Claims.</p>
<p>4. A base, carrier material, which allows passage of liquids, and exudates.</p>
<p>5. An adhesive layer if required to bond a Water-repellent cover.</p>
<p>6. A Water-repellent cover if required.</p>
<p>S</p>
<p>EXAMPLES</p>
<p>The invention is illustrated but not restricted by the following examples, which is not to be considered as limiting the scope of the protection as set out in the claims.</p>
<p>Example 1: (Ref. No: 46.15.04) A nonwoven base, carrier material (Ref. No: 47.05.44) was made with a weight of 220 g/m2, produced by a conventional carding, crossfolding, needling bonding route.</p>
<p>For this nonwoven base a 70/30, viscose / polyester fibre blend was used: 1. 70% 4.2 dtex, 60 mm Danufil V viscose (Acordis) 2. 30% 5.0 dtex, 60 mm Selenis T290 polyester The fibres were weighed and blended via weigh hoppers and beaters and fed to a volumetric fed Card to produce a lightweight web of fibres.</p>
<p>This fibrous web was laid down, in multiple layers, by a Crossfolder and the fleece produced was fed to a Needleloom where it was needled to provide the necessary strength for processing.</p>
<p>This nonwoven production route is well known to those experienced in nonwoven manufacture and provides a nonwoven construction which is absorbent and allows passage of liquid and Dried Active' material was made from Manuka Honey by MOLDA AG, Gartentstasse 13, D- 21368,Dahlenburg, Germany -using their commercial drying process. The Manuka Honey incorporated 5% Danisco alginate FD 120 as a drying agent.</p>
<p>The dried Active' material was mixed with a low melt co-polyester fusible powder adhesive (Dritex DT 135 from Dritex Ltd, Essex, UK a product with Melting Point approx. 65 deg. Celsius and particle size range 150 to 350 micron), in mixture of 82 parts Active' material to 1 8 parts Fusible powder.</p>
<p>This mixture was the applied to the special nonwoven base, carrier material at a level of 1 50g/m2 using a scatter coating process via a wire covered roller. This scatter process is well known and applies controlled amounts of powder by doctoring the powder particles into a rotating wire covered roller, brushing the powder out and allowing it to fall as a powder curtain onto the substrate to be coated. By controlling the roller speed the g/min of powder delivered can be set and by varying the coating speed of the substrate under the coating head the g/m2 onto the base substrate can be set.</p>
<p>After application of the dried Active' material / Fusible mixture, the coated material was passed though a Belt laminator at 90 C at 3.1 rn/mm with 1 bar pressure to partially melt the fusible powder adhesive and bond the Active' material.</p>
<p>In this process the material to be bonded or laminated is carried between two continuous top and bottom belts, through a heating zone where the temperature is sufficient to partially melt the adhesive components. The material then passes between pressure rollers (which can if needed be set to a specific gap) to facilitate the bonding or lamination. After cooling the bonded or laminated product can be wound up.</p>
<p>Because of the discrete nature of the dried Active' ingredient and the particle size of the fusible powder, the coating allows passage of liquid and wound exudate even after the bonding / laminating process.</p>
<p>During this bonding / laminating process, the coated nonwoven described above was also laminated with a low adherent, wound contact net (CB2I, a bi-extruded net from Smith & Nephew Extruded Films, East Yorkshire, UK, here one of the bi-extruded layers acts as a fusible adhesive) to produce the Wound Dressing product.</p>
<p>The net was introduced on top of the dried Active' ingredient coating as the material entered the two belts of the laminator.</p>
<p>The apertures in the net allow the passage of liquid and wound exudate.</p>
<p>In a further laminator pass a water repellent backing layer consisting of a 51 g/m2 hydroentangled polyester nonwoven with a fluorocarbon finish was laminated to the reverse side of the fleece using 9.5 g/m2 of the Dritex DTI 35 powder under the same laminating conditions.</p>
<p>This product was for use as a wound dressing where it can provide two properties, which are beneficial for wound healing: 1. Moist environment from alginate / honey when in contact with the wound exudates.</p>
<p>2. Natural anti-bacterial environment from the Manuka honey.</p>
<p>Example 2: (Ref. No: 46.15.07) A nonwoven base, carrier material (Ref. No: 81.01.05) was made with a weight of 180 g/m2, produced by a conventional carding, crossfolding, needling bonding route.</p>
<p>For this nonwoven base a 55/45, viscose / Anti-bacterial, Silver containing polyester fibre blend was used: 1. 55% 4.2 dtex, 60 mm Danufil V viscose (Acordis) 2. 45% 1.7 dtex, 38 mm Bacterbril polyester (Nurel, Spain) The fibres were weighed and blended via weigh hoppers and beaters and fed to a volumetric fed Card to produce a lightweight web of fibres.</p>
<p>This fibrous web was laid down, in multiple layers, by a Crossfolder and the fleece produced was fed to a Needleloom where it was needled to provide the necessary strength for processing.</p>
<p>This nonwoven production route is well known to those experienced in nonwoven manufacture and provides a nonwoven construction which is absorbent and allows passage of liquid and Dried Active' material was made from Manuka Honey by MOLDA AG, Gartentstasse 13, D- 21 368,Dahlenburg, Germany -using their commercial drying process. The Manuka Honey incorporated 5% Danisco alginate FD 120 as a drying agent.</p>
<p>The dried Active' material was mixed with a low melt co-polyester fusible powder adhesive (Dritex DT135 from Dritex Ltd, Essex, UK a product with Melting Point approx. 65 deg. Celsius and particle size range 1 50 to 350 micron), in mixture of 82 parts Active' material to 18 parts Fusible powder.</p>
<p>This mixture was the applied to the special nonwoven base, carrier material at a level of 300 g/m2 using a scatter coating process via a wire covered roller. This scatter process is well known and applies controlled amounts of powder by doctoring the powder particles into a rotating wire covered roller, brushing the powder out and allowing it to fall as a powder curtain onto the substrate to be coated. By controlling the roller speed the g/min of powder delivered can be set and by varying the coating speed of the substrate under the coating head the g/m2 onto the base substrate can be set.</p>
<p>After application of the dried Active' material / Fusible mixture, the coated material was passed though a Belt laminator at 90 C at 2.5 m/min with 1 bar pressure to partially melt the fusible powder adhesive and bond the Active' material.</p>
<p>In this process the material to be bonded or 1aiinated is carried between two continuous top and bottom belts, through a heating zone where the temperature is sufficient to partially melt the adhesive components. The material then passes between pressure rollers (which can if needed be set to a specific gap) to facilitate the bonding or lamination. After cooling the bonded or laminated product can be wound up.</p>
<p>Because of the discrete nature of the dried Active' ingredient and the particle size of the fusible powder, the coating allows passage of liquid and wound exudate even after the bonding / laminating process.</p>
<p>During this bonding / laminating process, the coated nonwoven described above was also laminated with a low adherent, wound contact net (CB21, a bi-extruded net from Smith & Nephew Extruded Films, East Yorkshire, UK, where one of the bi-extruded layers acts as a fusible adhesive) to produce the Wound Dressing product.</p>
<p>The net was introduced on top of the dried Active' ingredient coating as the material entered the two belts of the laminator.</p>
<p>The apertures in the net allow the passage of liquid and wound exudate.</p>
<p>In a further laminator pass a water repellent backing layer consisting of a 51 g/m2 hydroentangled polyester nonwoven with a fluorocarbon finish was laminated to the reverse side of the fleece using 9.5 g/m2 of the Dritex DT135 powder under the same laminating conditions.</p>
<p>This product was for use as a wound dressing where it can provide three properties, which are beneficial for wound healing: 1. Moist environment from alginate / honey when in contact with the wound exudates.</p>
<p>2. Natural anti-bacterial environment from the Manuka honey.</p>
<p>3. Anti-bacterial properties from the Silver in the anti-baëterial polyester.</p>
Claims (2)
- <p>Claims 1. A system to provide a layer of selected liquid Active'ingredients where the Active' ingredient is first converted to a dry form and which in a wound dressing can give improved
- 2. A system to provide a layer of selected liquid Active' ingredients where the Active' ingredient is first converted to a dry form in combination with an Active' powder or powders and which in a wound dressing can give improved wound healing.</p><p>3. A wound dressing product produced by the system according to claim 1.</p><p>4. A wound dressing product produced by the system according to claim 1 which has a construction to allow the passage of liquids and wound exudate to contact the Active' ingredients.</p><p>5. A wound dressing product produced by the system according to claim 2.</p><p>6. A wound dressing product produced by the system according to claim 2 which has a construction to allow the passage of liquids and wound exudate to contact the Active' ingredients.</p><p>7. A wound dressing product produced by the system according to claim 4 where the layer is obtained by use of dried liquid anti-bacterial Honey as the Active' ingredient.</p><p>8. A wound dressing product produced by the system according to claim 4 where the layer is obtained by use of dried liquid herbal extracts as the Active' ingredient.</p><p>9. A wound dressing product produced by the system according to claim 4 where the layer is obtained by use of dried liquid Essential oils as the Active' ingredient.</p><p>10. A wound dressing product produced by the system according to claim 4 where the layer incorporating dried liquid Active' ingredients is coated onto nonwoven base materials.</p><p>11. A wound dressing product produced according to claim 4 where the dried liquid Active' ingredients are held in place on the base, carrier material using a fusible adhesive.</p><p>12. A wound dressing product produced by the system according to claim 6 where the layer is obtained by use of dried liquid anti-bacterial Honey as the Active' liquid ingredient in combination with an alginate as the Active' dry ingredient.</p><p>13. A wound dressing product produced by the system according to claim 6 where the layer is obtained by use of dried liquid anti-bacterial Honey as the Active' liquid ingredient in combination with chitosan as the Active' dry ingredient.</p><p>14. A wound dressing product produced by the system according to claim 6 where the layer is obtained by use of dried liquid anti-bacterial Honey as the Active' liquid ingredient in combination with carboxy-methyl cellulose as the Active' dry ingredient.</p><p>15. A wound dressing product produced by the system according to claim 6 where the layer is obtained by use of dried liquid anti-bacterial Honey as the Active' liquid ingredient in combination with pectin as the Active' dry ingredient.</p><p>16. A wound dressing product produced by the system according to claim 6 where the layer is obtained by use of dried liquid herbal extracts as the Active' liquid ingredient in combination with alginate as the Active' dry ingredient.</p><p>17. A wound dressing product produced by the system according to claim 6 where the layer is obtained by use of dried liquid herbal extracts as the Active' liquid ingredient in combination with chitosan as the Active' dry ingredient.</p><p>18. A wound dressing product produced by the system according to claim 6 where the layer is obtained by use of dried liquid herbal extracts as the Active' liquid ingredient in combination with carboxy-methyl cellulose as the Active' dry ingredient.</p><p>19. A wound dressing product produced by the system according to claim 6 where the layer is obtained by use of dried liquid herbal extracts as the Active' liquid ingredient in combination with pectin as the Active' dry ingredient.</p><p>2. A wound dressing product produced by the stem according to claim 6 where the layer is obtained by use of dried liquid essential oils as the Active' liquid ingredient in combination with alginate as the Active' dry ingredient.</p><p>21. A wound dressing product produced by the system according to claim 6 where the layer is obtained by use of dried liquid essential oils as the Active' liquid ingredient in combination with chitosan as the Active' dry ingredient.</p><p>22. A wound dressing product produced by the system according to claim 6 where the layer is obtained by use of dried liquid essential oils as the Active' liquid ingredient in combination with carboxy-methyl cellulose as the Active' dry ingredient.</p><p>23. A wound dressing product produced by the system according to claim 6 where the layer is obtained by use of dried liquid essential oils as the Active' liquid ingredient in combination with pectin as the Active' dry ingredient.</p><p>24. A wound dressing product produced by the system according to claim 6 where the layer incorporating dried liquid Active' ingredients is coated onto nonwoven base materials.</p><p>25. A wound dressing product produced by the system according to claim 6 where the layer incorporating dried liquid Active' ingredients is coated onto nonwoven base materials incorporating other Active' ingredients.</p><p>26. A wound dressing product produced according to claim 6 where the dried liquid Active' ingredients and dry Active' ingredients are held in place on the base, carrier material using a fusible adhesive.</p><p>27. A wound dressing product according to claims 3 to 26 which incorporates a low adherent wound contact layer between the Active' ingredient layer(s) and the wound.</p><p>28. A wound dressing product according to claim 27 where the low adherent wound contact layer is a bi-extruded net where one of the bi-extruded layers acts as a fusible adhesive.</p><p>29. A wound dressing product according to claim 27 where the low adherent wound contact layer is a perforated film.</p><p>30. A wound dressing product according to claim 27 where the low adherent wound contact layer is a lightweight, polyester, thermally bonded nonwoven.</p><p>31. A wound dressing product according to claims 3 to 30 which incorporates a film or water repellent layer on the side opposing the wound contact side.</p><p>32. A wound dressing product according to claim 31 where the film is a polyurethane film.</p><p>33. A wound dressing product according to claim 31 where the water repellent layer comprises a hydroentangled polyester nonwoven with a fluorocarbon finish.</p><p>34. A medical device as described in claims 3 to 33 where the wound care device is presented as a wound dressing, wound covering or bandage format.</p>
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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GB0603630A GB2435426A (en) | 2006-02-23 | 2006-02-23 | Wound healing system and dressing containing a dried form of a liquid |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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GB0603630A GB2435426A (en) | 2006-02-23 | 2006-02-23 | Wound healing system and dressing containing a dried form of a liquid |
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GB0603630D0 GB0603630D0 (en) | 2006-04-05 |
GB2435426A true GB2435426A (en) | 2007-08-29 |
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GB0603630A Withdrawn GB2435426A (en) | 2006-02-23 | 2006-02-23 | Wound healing system and dressing containing a dried form of a liquid |
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Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2012134770A1 (en) * | 2011-03-25 | 2012-10-04 | Avery Dennison Corporation | Honey composition |
CN102886065A (en) * | 2012-10-29 | 2013-01-23 | 山西大学 | Traditional Chinese medicine combination used for medical polymer bandage |
ITMI20120180A1 (en) * | 2012-02-09 | 2013-08-10 | Marco Gandini | COMPOSITION FOR THE PREVENTION OF POST-OPERATIVE ADHERENCE |
CN109350762A (en) * | 2018-11-23 | 2019-02-19 | 北京诺康达医药科技股份有限公司 | A kind of medical dressing and preparation method thereof applied to chronic wound |
US11185080B2 (en) | 2014-04-30 | 2021-11-30 | Matoke Holdings Limited | Antimicrobial compositions |
US11730168B2 (en) | 2017-10-16 | 2023-08-22 | Matoke Holdings Limited | Antimicrobial superabsorbent compositions |
FR3143294A1 (en) * | 2022-12-14 | 2024-06-21 | L'oreal | Process for preparing an article, in particular a cosmetic article loaded with hydrophilic active ingredient in a dry form |
FR3143295A1 (en) * | 2022-12-14 | 2024-06-21 | L'oreal | Article in particular cosmetic adaptable to the shape of the face, neck and/or décolleté and loaded with hydrophilic active ingredient |
FR3143293A1 (en) * | 2022-12-14 | 2024-06-21 | L'oreal | Article in particular cosmetic adaptable to the shape of the face, neck and/or décolleté comprising a support made of regenerated cellulose fibers and loaded with solid active ingredient |
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Cited By (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2012134770A1 (en) * | 2011-03-25 | 2012-10-04 | Avery Dennison Corporation | Honey composition |
ITMI20120180A1 (en) * | 2012-02-09 | 2013-08-10 | Marco Gandini | COMPOSITION FOR THE PREVENTION OF POST-OPERATIVE ADHERENCE |
CN102886065A (en) * | 2012-10-29 | 2013-01-23 | 山西大学 | Traditional Chinese medicine combination used for medical polymer bandage |
CN102886065B (en) * | 2012-10-29 | 2014-06-18 | 山西大学 | Traditional Chinese medicine combination used for medical polymer bandage |
US11185080B2 (en) | 2014-04-30 | 2021-11-30 | Matoke Holdings Limited | Antimicrobial compositions |
US11311017B2 (en) | 2014-04-30 | 2022-04-26 | Matoke Holdings Limited | Antimicrobial compositions |
US11730168B2 (en) | 2017-10-16 | 2023-08-22 | Matoke Holdings Limited | Antimicrobial superabsorbent compositions |
CN109350762A (en) * | 2018-11-23 | 2019-02-19 | 北京诺康达医药科技股份有限公司 | A kind of medical dressing and preparation method thereof applied to chronic wound |
CN109350762B (en) * | 2018-11-23 | 2021-07-23 | 北京诺康达医药科技股份有限公司 | Medical dressing applied to chronic wound surface and preparation method thereof |
FR3143294A1 (en) * | 2022-12-14 | 2024-06-21 | L'oreal | Process for preparing an article, in particular a cosmetic article loaded with hydrophilic active ingredient in a dry form |
FR3143295A1 (en) * | 2022-12-14 | 2024-06-21 | L'oreal | Article in particular cosmetic adaptable to the shape of the face, neck and/or décolleté and loaded with hydrophilic active ingredient |
FR3143293A1 (en) * | 2022-12-14 | 2024-06-21 | L'oreal | Article in particular cosmetic adaptable to the shape of the face, neck and/or décolleté comprising a support made of regenerated cellulose fibers and loaded with solid active ingredient |
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GB0603630D0 (en) | 2006-04-05 |
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