https://lnkd.in/dWZmUakc We, the VivacelleBio team proud to present our Ph 2a study results published in The Lancet. #VBI-S #SepticShock #Hypotension #MAPimprovement
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For curious minds, learn more about the work we aim to catalyze for lymphatic medicine and why it’s important:
ARPA-H launches program to catalyze transformative advances in lymphatic medicine
arpa-h.gov
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📢New Special Issue launched! Addressing Coagulation and Inflammation to Prevent and Treat Ischemic Stroke 🔗 https://lnkd.in/gdNjQsjy 👨🔬Guest Editor: Prof. Antonino Tuttolomondo 📅Deadline: November 30, 2024 Welcome to submit your work to discuss together! As an author, you can benefit from Google Scholar, CAS, and DOAJ indexing, open access publication, and no Article Processing Charges before July 31, 2026. Plus, authors retain copyright, and the research will be widely promoted. This special issue will summarize the role of inflammation in the pathogenesis of ischemic stroke and the involvement of the main coagulative factors involved in estrinsic and intrinsic mechanisms of the coagulation in brain ischemic damage. Contact for more information and submission details: [email protected] #callforpaper #ischemic #stroke #inflammation #coagulation #hemostasis #thrombosis
Special Issue: Addressing Coagulation and Inflammation to Prevent and Treat Ischemic Stroke
explorationpub.com
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Dallas campus medical director and a national leader in CV research, Robert C. Stoler MD, FACC, FSCAI, is one of the lead authors on the JAMA Network March 9th article Paclitaxel-Coated Balloon vs Uncoated Balloon for Coronary In-Stent Restenosis. The article provides an overview of AGENT IDE, a multicenter randomized trial of 600 patients designed to evaluate paclitaxel-coated balloon as a treatment strategy for in-stent restenosis. Findings indicate that target lesion failure was significantly lower in the paclitaxel-coated balloon group. Read the key points. https://lnkd.in/exvdSb-B
Paclitaxel-Coated Balloon vs Uncoated Balloon for Coronary In-Stent Restenosis
jamanetwork.com
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📚 New Research Alert! 🚀 Check out this fascinating article: "Myopia progression following 0.01% atropine cessation in Australian children: Findings from the Western Australia - Atropine for the Treatment of Myopia (WA-ATOM) study" by SS Lee, VK Nilagiri, G Lingham, M Blaszkowska et al- Clin Exp Ophthalmol. 2024. 🔍 Background: The study aimed to investigate the rebound effect of myopia progression after cessation of 0.01% atropine compared to a placebo control. 🔬 Key Findings: During the 1-year wash-out phase, myopia progression was faster in the treatment group than in the control group. Over the 3-year study period, cumulative myopia progression was similar between the atropine and control groups. 💡 Clinical Translation: This study emphasizes: The need for prolonged atropine administration to avoid a rebound effect, even with lower concentrations. The possibility of resuming atropine treatment if abnormal axial length progression occurs after discontinuation. 📌 Take Home Message: Stay informed about the latest research in myopia management and ensure optimal treatment strategies for your patients! Learn more by reading the AAOMC Newsletter, The Corrected View E-Tea: https://lnkd.in/grUQdMRu #MyopiaResearch #AtropineStudy #EyeHealth #ClinicalResearch #Optometry #Ophthalmology #MyopiaManagement #AAOMC
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When cells receive higher than normal damages they are likely to enter a state known as cellular senescence. Senescent cells are not able to proliferate but secrete many factors with pro-inflammatory and pro-disease functions. In this study, we show that patients with severe Covid-19 express markers of cellular senescence in the blood, and we identify a specific population of senescent immune cells. We provide compelling evidence for a novel mechanism regulating the long-term pathological consequences of Sars-CoV2 infection, and a potential target for therapeutic interventions. #senescence #covid19 #monocytes https://lnkd.in/eqFJDbJN
Happy to share our latest study on the identification of monocytes expressing senescence signatures in the blood of patients with severe Covid-19. Great collaborative effort with Hjalmar Bouma and Douwe Postma from the Dept of Internal Medicine of the UMCG, and with the group of James Kirkland. #senescence #covid19 #covid19research #aging ERIBA - European Research Institute for the Biology of Ageing UMCG research https://lnkd.in/eiG_W3eZ
Circulating monocytes expressing senescence‐associated features are enriched in COVID‐19 patients with severe disease
onlinelibrary.wiley.com
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System Shaper | Problem Solver | Leading Teams Who Transform Medicine | Mentor & Coach | Passionate about Women's Health, Diversity, Equity, & Inclusion
Absolutely, Linda Griffith! It's truly astonishing how little we know about the science behind conditions like #endometriosis and #adenomyosis, which impact so many women. We can't accept this status quo any longer. It's high time for innovative therapies and diagnostics. Women have waited far too long. Thanks to leaders like you we are asking the harder questions to change this reality. Your Open Endoscopy Forum Gynecology Science and Technology Workshop this Friday, Sept. 22 is a great start: https://cgr.mit.edu/oef/ 💥Not so fun facts that fire me up: Endometriosis affects 1 in 10 women. ⭐️ The estimated US economic burden is a staggering $78–119 billion annually. ⭐️ Women often wait 8 to 12 years for a diagnosis. ⭐️ Black women are 50% less likely to be diagnosed compared to white women. Adenomyosis affects 1 in 5 women. ⭐️ Rates are approximately 60% higher in black women compared to white women. ⭐️ While the economic burden lacks a reliable statistic, it's undoubtedly BIG. ⭐️ There are no approved medical guidelines or therapeutic treatments, with the "gold standard" being hysterectomy. We urgently need forums that encourage dialogue and collaboration among all stakeholders, and MIT could be the catalyst for this change. Let's roll up our sleeves and make it happen! 💪🔬 #CollaborationMatters #WomensHealth
Astonishing - and astonishingly accurate - quote about adenomyosis, hot of the press today : "The lack of information about the nature and pathophysiology of adenomyosis and the paucity of a proper universal classification system has led to a near anarchy in the treatment of this disease." And this is why it is SO HARD to get pharma to take on endo and adeno. We need MIT to serve as a convener of all the stakeholders out there, to cut through this Gordian knot. I know Stephanie Sassman is listening to my agony on this - and to my proposed path to solutions! https://lnkd.in/ePM6N2Ca
The Asian Society of Endometriosis and Adenomyosis guidelines for managing adenomyosis
onlinelibrary.wiley.com
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Exciting news! my paper is recently accepted in Geroscience. It delves into the world of cellular senescence in osteoarthritis, uncovering two senescence endotypes. Even more fascinating, we identified potential blood-biomarkers to fascilitate personalised treatment for OA patients! 🦴💡Read it here: https://rdcu.be/drCDn
Identified senescence endotypes in aged cartilage are reflected in the blood metabolome - GeroScience
link.springer.com
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I am very pleased to announce the publication of my latest research paper and would like to thank all co-authors for their valuable contributions. 🧬 In this work, we investigated the role of BMP9 on vascular homeostasis and endothelial cell identity. We show that BMP9 is required for the correct identity of liver endothelial cells and that its loss leads to dilated vascular vessels in multiple organs (liver, brain, kidney, lung). We have also demonstrated for the first time that BMP9 deletion is sufficient to induce arteriovenous shunting and malformations, reminiscent of what can be observed in HHT patients. Overall, we demonstrate that BMP9 plays a key role in the pathogenesis of HHT. ⬇️ if you want to know more, follow the link : https://lnkd.in/dESH4Aux Authors A Desroches-Castan, D Koca, H Liu, C Roelants, L Resmini, N Ricard, C Bouvard, N Chaumontel, P L Tharaux, E Tillet, C Battail, O Lenoir, S Bailly #endothelialcells #vasculardiseases #raredisease #HHT #PAH #ResearchPublication
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Our recent research, titled "Exploring the Underlying Mechanisms of Ischemic Heart Disease Post-Stroke: Insights from a 2-Year Follow-Up Investigation," has been published in the Annals of Gerontology and Geriatric Research! This paper addresses a critical gap in current research by extending the temporal scope of risk prediction models, emphasizing the importance of considering a 2-year follow-up period for patients with ischemic stroke in the ICU. The utilization of machine learning techniques underscores a commitment to innovative and data-driven approaches in healthcare, with the ultimate goal of improving patient outcomes and refining clinical decision-making in this specific medical context. A heartfelt thank you to the dedicated team, collaborators, and everyone involved in making this research a reality. Your contributions are invaluable! 📚 Read the Full Paper https://lnkd.in/gEmHGJTh #Research #Cardiology #Geriatrics #Stroke #HeartDisease #AcademicPublishing #MedicalResearch #Science #HealthInsights
Exploring the Underlying Mechanisms of Ischemic Heart Disease Post-Stroke: Insights from a 2-Year Follow-Up Investigation
jscimedcentral.com
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#ABCWIN2024 #INReporters 𝗙𝗲𝘁𝗮𝗹 𝗘𝗺𝗯𝗼𝗹𝗶𝘇𝗮𝘁𝗶𝗼𝗻 𝗼𝗳 𝗩𝗲𝗶𝗻 𝗼𝗳 𝗚𝗮𝗹𝗲𝗻 𝗠𝗮𝗹𝗳𝗼𝗿𝗺𝗮𝘁𝗶𝗼𝗻 (VGAM) 👉 Dr. Orbach presented an innovative work on Fetal Embolization of VGAM. It consists in a very severe disease leading to a poor outcome with around 30% mortality before 1YO. Even in case of “good outcome” many will have neurodevelopmental issues & this, despite tremendous progress done in VGAM treatment. Embolization has a high rate of periprocedural complications (30% morbidity & 15% mortality for Toronto's team). ➡️ In utero placenta seems to provide a protecting effect acting as a sump due to its low resistance & delivery will then put the high flow burden entirely on heart / brain. So there is a rational to try to intervene before cascade of events leading to bad outcomes. The predictive factor, targeting this ”Neonatal at risk population“ (65% of all cases) is a 𝙨𝙩𝙧𝙖𝙞𝙜𝙝𝙩 / 𝙛𝙖𝙡𝙘𝙞𝙣𝙚 𝙨𝙞𝙣𝙪𝙨 𝙬𝙞𝙙𝙩𝙝 𝙬𝙞𝙩𝙝 𝙖 𝙘𝙪𝙩 𝙤𝙛𝙛 𝙖𝙩 𝙢𝙤𝙧𝙚 𝙩𝙝𝙖𝙣 7𝙢𝙢. ➡️ Clinical trial early results about the first 2 successfully cases : - under ultrasound guidance, percutaneously, he inserted a needle (18 G) through the fetal skull into the torcular then anteriorly through the falcine sinus into the varix. - then deployed coils through a .021 microcatheter. ➡️ Postnatal echocardio demonstrated back to an antegrade flow in the aortic within a few days. There were no need for neonatal endovascular intervention, nor cardiovascular support & neurological examination was normal. 💡 Let’s keep a eye on further results 📝 https://lnkd.in/eM7pMsXD 💡 𝐒𝐭𝐚𝐲 𝐭𝐮𝐧𝐞𝐝 𝘋𝘳. 𝘈𝘯𝘯𝘦-𝘊𝘩𝘳𝘪𝘴𝘵𝘪𝘯𝘦 𝘑𝘢𝘯𝘶𝘦𝘭 & P𝘳. 𝘑𝘦𝘢𝘯-𝘊𝘩𝘳𝘪𝘴𝘵𝘰𝘱𝘩𝘦 𝘎𝘦𝘯𝘵𝘳𝘪𝘤 Content dedicated for an international audience
Transuterine Ultrasound-Guided Fetal Embolization of Vein of Galen Malformation, Eliminating Postnatal Pathophysiology
ahajournals.org
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