All of Us is shaping how we understand health and disease. Research Highlights showcase the recent research powered by All of Us data and tools.
Featured Highlight
Rare Finding in All of Us Data Affects DNA Testing for Certain Cancer Drugs
Experts thought that two variants in the DPYD gene always occurred together. A recent study of DNA data from more than 245,000 All of Us participants found that the variants do not always occur together. This finding has changed how health care providers use DNA tests to decide on the right dose of certain cancer treatments.
All of Us Data Shows That Many People With Diabetes Are Undertreated
Researchers looked at All of Us data to study whether people with diabetes are getting statins and other medicines to reduce their risk of heart disease and stroke. About half of the participants were not. Thanks to All of Us participants, we now know more about the need for better management of heart disease risk in people with diabetes.
All of Us Helps Link Health Conditions With Severe COVID-19 Risk
A study linked 27 health conditions, including obesity, substance use disorders, and breathing problems, to the risk of severe COVID-19 in people of European ancestry. This study involved data from DNA and health records from more than half a million participants from three databases, including All of Us.
Exploring Polygenic Risk Scores Using All of Us
Polygenic risk scores are a measure of how likely you are to get a particular health condition—your risk—based on changes in many genes in your DNA. However, these scores are often most accurate for people of European ancestry, because past research left out many other groups. Researchers adjusted polygenic risk scores for 10 common conditions using the diverse genetic data in All of Us so that the scores are accurate for people from a variety of backgrounds.
All of Us Data Shows the Effect of Resilience in Difficult Times
A study of All of Us survey data confirmed that feelings of depression increased during the COVID-19 pandemic, particularly among participants who experienced discrimination. Having a high level of resilience lessened the effect of discrimination on mental health in some racial and ethnic groups.
Learning About the Health of Young Cancer Survivors With All of Us
The long-term health of teens and young adults who have had cancer has not been well studied. A look at All of Us data showed that young cancer survivors were more likely to have certain brain- and nerve-related conditions than participants who never had cancer. This age group may need unique treatment and management plans.