unrest (n.)

[sleep, repose, slumber] Old English ræste, reste "rest; a bed or couch; intermission of labor; mental peace, state of quiet or repose," from Proto-Germanic *rasto- (source also of Old Saxon resta "resting place, burial-place," Dutch rust, Old High German rasta, German Rast "rest, peace, repose"), a word of uncertain origin.

The original prehistoric signification of the Germanic noun was perhaps a measure of distance; compare Old High German rasta, which in addition to "rest" meant "league of miles," Old Norse rost "league, distance after which one rests," Gothic rasta "mile, stage of a journey." If so, perhaps a word from the nomadic period. But if the original sense was "repose," the sense was extended secondarily to "distance between two resting places."

Sense of "absence or cessation of motion" is from late 15c. The meaning "that on which anything leans for support, thing upon which something rests" is attested from 1580s, with specific senses developing later. In music, "an interval of silence," also the mark or sign denoting this, 1570s.

At rest "dead" is from mid-14c., on the notion of "last rest, the big sleep, the grave." The roadside rest stop for drivers on busy highways is by 1970. The colloquial expression give (something) a rest "stop talking about it" is by 1927, American English.

[R]est and repose apply especially to the suspended activity of the body ; ease and quiet to freedom from occupation or demands for activity, especially of the body ; tranquility and peace to the freedom of the mind from harassing cares or demands. [Century Dictionary]

prefix of negation, Old English un-, from Proto-Germanic *un- (source also of Old Saxon, Old Frisian, Old High German, German un-, Gothic un-, Dutch on-), from PIE *n- (source of Sanskrit a-, an- "not," Greek a-, an-, Old Irish an-, Latin in-), combining form of PIE root *ne- "not." Often euphemistic (such as untruth for "lie").

The most prolific of English prefixes, freely and widely used in Old English, where it forms more than 1,000 compounds. It underwent a mass extinction in early Middle English, but emerged with renewed vigor 16c. to form compounds with native and imported words. It disputes with Latin-derived cognate in- (1) the right to form the negation of certain words (indigestable/undigestable, etc.), and though both might be deployed in cooperation to indicate shades of meaning (unfamous/infamous), typically they are not.

It also makes words from phrases (such as uncalled-for, c. 1600; undreamed-of, 1630s; uncome-at-able, 1690s; unputdownable, 1947, of a book; un-in-one-breath-utterable, Ben Jonson; etc., but the habit is not restricted to un-; such as put-up-able-with, 1812). As a prefix in telegramese to replace not and save the cost of a word, it is attested by 1936.