Cambridge International AS & A Level: Biology 9700/12
Cambridge International AS & A Level: Biology 9700/12
BIOLOGY 9700/12
Paper 1 Multiple Choice October/November 2022
1 hour 15 minutes
INSTRUCTIONS
• There are forty questions on this paper. Answer all questions.
• For each question there are four possible answers A, B, C and D. Choose the one you consider correct
and record your choice in soft pencil on the multiple choice answer sheet.
• Follow the instructions on the multiple choice answer sheet.
• Write in soft pencil.
• Write your name, centre number and candidate number on the multiple choice answer sheet in the
spaces provided unless this has been done for you.
• Do not use correction fluid.
• Do not write on any bar codes.
• You may use a calculator.
INFORMATION
• The total mark for this paper is 40.
• Each correct answer will score one mark.
• Any rough working should be done on this question paper.
IB22 11_9700_12/5RP
© UCLES 2022 [Turn over
2
1 The diagram shows a stage micrometer, with divisions 0.10 mm apart, viewed through an
eyepiece containing a graticule.
0 10 20 30 40 50 60 70 80 90 10
The area of the field of view of the microscope can be calculated using this formula.
area = πr2
A student calculated the area of the field of view of the microscope using the information provided
and a value for π of 3.142.
Which answer has been rounded correctly to an appropriate number of significant figures?
A 0.04909 mm2
B 5 × 10–2 mm2
1 endoplasmic reticulum
2 Golgi body
3 mitochondria
1 thymine
2 adenine
3 cytosine
6 The table shows the observations recorded from tests for biological molecules on four samples,
A, B, C and D.
A B
CH2OH H
C O H C OH
H H
H
C C H C OH
OH H
HO OH
C C H C OH
H OH
H
C D
NH2 CH2OH
N C O
N H OH
H
C C
HO OH H
N N HO H
O C C
C C
H OH
C C
OH OH
A fructose
B glucose
C maltose
D sucrose
CH2OH
O H
OH
O X
OH
CH2OH CH2OH CH2 CH2OH
O H O H O H O H
OH OH OH OH
O O O
OH OH OH OH
11 Silk moth caterpillars have been genetically modified to produce a mixture of their own silk and
the much stronger spider silk of the golden orb web spider.
The spider silk polypeptide chain has many repeated sequences of two amino acids, glycine and
alanine, arranged in a crystalline structure.
12 Which property of the tertiary structure of a globular protein enables it to catalyse a metabolic
reaction?
X
activity of
enzyme
substrate concentration
An increase in which factors could lead to a change in the activity of the enzyme at point X on the
graph?
1 pH
2 substrate concentration
3 temperature
14 The Michaelis–Menten constant, Km, is the substrate concentration at which an enzyme works at
half its maximum rate.
A The enzyme has a low affinity for the substrate and the quicker the reaction will proceed to
its maximum rate.
B The enzyme has a low affinity for the substrate and the slower the reaction will proceed to its
maximum rate.
C The enzyme has a high affinity for the substrate and the quicker the reaction will proceed to
its maximum rate.
D The enzyme has a high affinity for the substrate and the slower the reaction will proceed to
its maximum rate.
15 Which functions are performed by glycoproteins on the surface of a cell surface membrane?
16 The diagram represents a process by which molecules move out of a cell through a cell surface
membrane.
A exocytosis
B diffusion
C facilitated diffusion
D osmosis
17 The photomicrograph shows the appearance of onion epidermal cells after they have been
soaked in solution X for one hour.
A air
B cytoplasm
C solution X
D water
18 The enzyme telomerase prevents loss of telomeres after many mitotic cell cycles.
1 cancer cells
2 stem cells
3 activated memory B-lymphocytes
19 Which processes that occur in the cell cycle are represented in the diagram?
3
mass of nuclear
DNA in a cell 2
/ arbitrary units
1
0
time
20 A gene codes for the production of a protein, p53, that binds to damaged DNA during interphase
and prevents its replication. A carcinogen in cigarette smoke mutates the gene coding for the p53
protein, preventing production of the protein.
22 How many statements about semi-conservative replication of DNA in a eukaryotic cell are
correct?
A 1 B 2 C 3 D 4
23 A section of the polypeptide coding for the haemoglobin β-chain contains the following amino
acids.
Patients with sickle cell anaemia have mutated β-polypeptide chains. The section of the mutated
polypeptide contains the following amino acids.
Val CAA
Val CAG
Val CAC
Val CAU
What is the corresponding DNA triplet code for the substituted amino acid in the mutated
polypeptide?
A B C D
A U C G G C T U
25 The diagram shows part of the DNA sequence of a gene and a mutated sequence of the same
gene.
normal DNA sequence ... CCG GAT TAT TGC GAG AAA TGG CAT TCT AGG ...
mutated DNA sequence ... CCG GAT GTA TTG CGA GAA ATG CAT TCT AGG ...
26 The electron micrograph shows a longitudinal section through part of a plant stem.
What is X?
27 Sodium chloride is added to a culture solution containing freshwater single-celled plant cells.
What happens to the water potential of the culture solution when the sodium chloride is added
and what may happen to the plant cells after 5 minutes?
29 Which statement about the movement of water from roots to leaves is not correct?
30 Which terms describe the method by which water is transported within xylem vessel elements?
1 cotransport
2 cohesion-tension
3 osmosis
A providing cytoplasmic contact with the sieve tube element for loading
B providing structural support for the sieve tube element
C providing the nucleus for cell division in the phloem
D providing the source of assimilates for storage
A
C
33 The table shows some information about three blood vessels, P, Q and R, from a mammal.
P 25 2 22 33 40
Q 20 1 25 40 25
R 4 1 35 25 30
P Q R
34 Ventricular septal defect (VSD) is a heart defect that people can have from birth. People with
VSD have a hole in the wall (septum) that separates the left and right ventricles.
1 Blood will leak through the hole, mostly from right to left.
2 The volume of blood circulating through the lungs will be higher than in a person
without VSD.
3 Less oxygen will be delivered to the body tissues.
A The semilunar valves close when the pressure in the ventricles falls lower than the pressure
in the arteries.
B A muscle called the septum separates the atria from the ventricles.
C There is a small patch of tissue in the right atrium that acts to delay the electrical impulse.
D Closure of valves in the veins prevents backflow of blood into the ventricles.
elastic
cartilage cilia
fibres
A key
B = present
C = not present
D
1 to move mucus
2 to trap pathogens and dust
3 to increase the surface area
1 2 3
A key
B = a function
C = not a function
D
38 Cholera and tuberculosis are infectious diseases that can spread when people have to live in
overcrowded conditions.
Which strategies would help control the spread of cholera and tuberculosis?
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