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* [[HOXB1]],<ref name = pmid9482740>{{cite journal | vauthors = Berthelsen J, Zappavigna V, Ferretti E, Mavilio F, Blasi F | title = The novel homeoprotein Prep1 modulates Pbx-Hox protein cooperativity | journal = The EMBO Journal | volume = 17 | issue = 5 | pages = 1434–45 | date = Mar 1998 | pmid = 9482740 | pmc = 1170491 | doi = 10.1093/emboj/17.5.1434 }}</ref><ref name = pmid10052460>{{cite journal | vauthors = Piper DE, Batchelor AH, Chang CP, Cleary ML, Wolberger C | title = Structure of a HoxB1-Pbx1 heterodimer bound to DNA: role of the hexapeptide and a fourth homeodomain helix in complex formation | journal = Cell | volume = 96 | issue = 4 | pages = 587–97 | date = Feb 1999 | pmid = 10052460 | doi = 10.1016/S0092-8674(00)80662-5}}</ref>
* [[HOXB1]],<ref name = pmid9482740>{{cite journal | vauthors = Berthelsen J, Zappavigna V, Ferretti E, Mavilio F, Blasi F | title = The novel homeoprotein Prep1 modulates Pbx-Hox protein cooperativity | journal = The EMBO Journal | volume = 17 | issue = 5 | pages = 1434–45 | date = Mar 1998 | pmid = 9482740 | pmc = 1170491 | doi = 10.1093/emboj/17.5.1434 }}</ref><ref name = pmid10052460>{{cite journal | vauthors = Piper DE, Batchelor AH, Chang CP, Cleary ML, Wolberger C | title = Structure of a HoxB1-Pbx1 heterodimer bound to DNA: role of the hexapeptide and a fourth homeodomain helix in complex formation | journal = Cell | volume = 96 | issue = 4 | pages = 587–97 | date = Feb 1999 | pmid = 10052460 | doi = 10.1016/S0092-8674(00)80662-5}}</ref>
* [[HOXB7]],<ref name = pmid7729685>{{cite journal | vauthors = Chang CP, Shen WF, Rozenfeld S, Lawrence HJ, Largman C, Cleary ML | title = Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins | journal = Genes & Development | volume = 9 | issue = 6 | pages = 663–74 | date = Mar 1995 | pmid = 7729685 | doi = 10.1101/gad.9.6.663}}</ref>
* [[HOXB7]],<ref name = pmid7729685>{{cite journal | vauthors = Chang CP, Shen WF, Rozenfeld S, Lawrence HJ, Largman C, Cleary ML | title = Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins | journal = Genes & Development | volume = 9 | issue = 6 | pages = 663–74 | date = Mar 1995 | pmid = 7729685 | doi = 10.1101/gad.9.6.663}}</ref>
* [[MEIS1]],<ref name = pmid10082572>{{cite journal | vauthors = Shen WF, Rozenfeld S, Kwong A, Köm ves LG, Lawrence HJ, Largman C | title = HOXA9 forms triple complexes with PBX2 and MEIS1 in myeloid cells | journal = Molecular and Cellular Biology | volume = 19 | issue = 4 | pages = 3051–61 | date = Apr 1999 | pmid = 10082572 | pmc = 84099 | doi = }}</ref><ref name = pmid10523646>{{cite journal | vauthors = Shanmugam K, Green NC, Rambaldi I, Saragovi HU, Featherstone MS | title = PBX and MEIS as non-DNA-binding partners in trimeric complexes with HOX proteins | journal = Molecular and Cellular Biology | volume = 19 | issue = 11 | pages = 7577–88 | date = Nov 1999 | pmid = 10523646 | pmc = 84774 | doi = }}</ref><ref name = pmid10373562>{{cite journal | vauthors = Jacobs Y, Schnabel CA, Cleary ML | title = Trimeric association of Hox and TALE homeodomain proteins mediates Hoxb2 hindbrain enhancer activity | journal = Molecular and Cellular Biology | volume = 19 | issue = 7 | pages = 5134–42 | date = Jul 1999 | pmid = 10373562 | pmc = 84356 | doi = }}</ref> and
* [[MEIS1]],<ref name = pmid10082572>{{cite journal | vauthors = Shen WF, Rozenfeld S, Kwong A, Köm ves LG, Lawrence HJ, Largman C | title = HOXA9 forms triple complexes with PBX2 and MEIS1 in myeloid cells | journal = Molecular and Cellular Biology | volume = 19 | issue = 4 | pages = 3051–61 | date = Apr 1999 | pmid = 10082572 | pmc = 84099 | doi = 10.1128/MCB.19.4.3051}}</ref><ref name = pmid10523646>{{cite journal | vauthors = Shanmugam K, Green NC, Rambaldi I, Saragovi HU, Featherstone MS | title = PBX and MEIS as non-DNA-binding partners in trimeric complexes with HOX proteins | journal = Molecular and Cellular Biology | volume = 19 | issue = 11 | pages = 7577–88 | date = Nov 1999 | pmid = 10523646 | pmc = 84774 | doi = 10.1128/MCB.19.11.7577}}</ref><ref name = pmid10373562>{{cite journal | vauthors = Jacobs Y, Schnabel CA, Cleary ML | title = Trimeric association of Hox and TALE homeodomain proteins mediates Hoxb2 hindbrain enhancer activity | journal = Molecular and Cellular Biology | volume = 19 | issue = 7 | pages = 5134–42 | date = Jul 1999 | pmid = 10373562 | pmc = 84356 | doi = 10.1128/MCB.19.7.5134}}</ref> and
* [[PKNOX1|Prep1]].<ref name = pmid16705164>{{cite journal | vauthors = Zubair M, Ishihara S, Oka S, Okumura K, Morohashi K | title = Two-step regulation of Ad4BP/SF-1 gene transcription during fetal adrenal development: initiation by a Hox-Pbx1-Prep1 complex and maintenance via autoregulation by Ad4BP/SF-1 | journal = Molecular and Cellular Biology | volume = 26 | issue = 11 | pages = 4111–21 | date = Jun 2006 | pmid = 16705164 | pmc = 1489093 | doi = 10.1128/MCB.00222-06 }}</ref>
* [[PKNOX1|Prep1]].<ref name = pmid16705164>{{cite journal | vauthors = Zubair M, Ishihara S, Oka S, Okumura K, Morohashi K | title = Two-step regulation of Ad4BP/SF-1 gene transcription during fetal adrenal development: initiation by a Hox-Pbx1-Prep1 complex and maintenance via autoregulation by Ad4BP/SF-1 | journal = Molecular and Cellular Biology | volume = 26 | issue = 11 | pages = 4111–21 | date = Jun 2006 | pmid = 16705164 | pmc = 1489093 | doi = 10.1128/MCB.00222-06 }}</ref>


Line 28: Line 28:
* {{cite journal | vauthors = Berthelsen J, Zappavigna V, Ferretti E, Mavilio F, Blasi F | title = The novel homeoprotein Prep1 modulates Pbx-Hox protein cooperativity | journal = The EMBO Journal | volume = 17 | issue = 5 | pages = 1434–45 | date = Mar 1998 | pmid = 9482740 | pmc = 1170491 | doi = 10.1093/emboj/17.5.1434 }}
* {{cite journal | vauthors = Berthelsen J, Zappavigna V, Ferretti E, Mavilio F, Blasi F | title = The novel homeoprotein Prep1 modulates Pbx-Hox protein cooperativity | journal = The EMBO Journal | volume = 17 | issue = 5 | pages = 1434–45 | date = Mar 1998 | pmid = 9482740 | pmc = 1170491 | doi = 10.1093/emboj/17.5.1434 }}
* {{cite journal | vauthors = Piper DE, Batchelor AH, Chang CP, Cleary ML, Wolberger C | title = Structure of a HoxB1-Pbx1 heterodimer bound to DNA: role of the hexapeptide and a fourth homeodomain helix in complex formation | journal = Cell | volume = 96 | issue = 4 | pages = 587–97 | date = Feb 1999 | pmid = 10052460 | doi = 10.1016/S0092-8674(00)80662-5 }}
* {{cite journal | vauthors = Piper DE, Batchelor AH, Chang CP, Cleary ML, Wolberger C | title = Structure of a HoxB1-Pbx1 heterodimer bound to DNA: role of the hexapeptide and a fourth homeodomain helix in complex formation | journal = Cell | volume = 96 | issue = 4 | pages = 587–97 | date = Feb 1999 | pmid = 10052460 | doi = 10.1016/S0092-8674(00)80662-5 }}
* {{cite journal | vauthors = Shen WF, Rozenfeld S, Kwong A, Köm ves LG, Lawrence HJ, Largman C | title = HOXA9 forms triple complexes with PBX2 and MEIS1 in myeloid cells | journal = Molecular and Cellular Biology | volume = 19 | issue = 4 | pages = 3051–61 | date = Apr 1999 | pmid = 10082572 | pmc = 84099 | doi = }}
* {{cite journal | vauthors = Shen WF, Rozenfeld S, Kwong A, Köm ves LG, Lawrence HJ, Largman C | title = HOXA9 forms triple complexes with PBX2 and MEIS1 in myeloid cells | journal = Molecular and Cellular Biology | volume = 19 | issue = 4 | pages = 3051–61 | date = Apr 1999 | pmid = 10082572 | pmc = 84099 | doi = 10.1128/MCB.19.4.3051}}
* {{cite journal | vauthors = Jacobs Y, Schnabel CA, Cleary ML | title = Trimeric association of Hox and TALE homeodomain proteins mediates Hoxb2 hindbrain enhancer activity | journal = Molecular and Cellular Biology | volume = 19 | issue = 7 | pages = 5134–42 | date = Jul 1999 | pmid = 10373562 | pmc = 84356 | doi = }}
* {{cite journal | vauthors = Jacobs Y, Schnabel CA, Cleary ML | title = Trimeric association of Hox and TALE homeodomain proteins mediates Hoxb2 hindbrain enhancer activity | journal = Molecular and Cellular Biology | volume = 19 | issue = 7 | pages = 5134–42 | date = Jul 1999 | pmid = 10373562 | pmc = 84356 | doi = 10.1128/MCB.19.7.5134}}
* {{cite journal | vauthors = Knoepfler PS, Bergstrom DA, Uetsuki T, Dac-Korytko I, Sun YH, Wright WE, Tapscott SJ, Kamps MP | title = A conserved motif N-terminal to the DNA-binding domains of myogenic bHLH transcription factors mediates cooperative DNA binding with pbx-Meis1/Prep1 | journal = Nucleic Acids Research | volume = 27 | issue = 18 | pages = 3752–61 | date = Sep 1999 | pmid = 10471746 | pmc = 148632 | doi = 10.1093/nar/27.18.3752 }}
* {{cite journal | vauthors = Knoepfler PS, Bergstrom DA, Uetsuki T, Dac-Korytko I, Sun YH, Wright WE, Tapscott SJ, Kamps MP | title = A conserved motif N-terminal to the DNA-binding domains of myogenic bHLH transcription factors mediates cooperative DNA binding with pbx-Meis1/Prep1 | journal = Nucleic Acids Research | volume = 27 | issue = 18 | pages = 3752–61 | date = Sep 1999 | pmid = 10471746 | pmc = 148632 | doi = 10.1093/nar/27.18.3752 }}
* {{cite journal | vauthors = McWhirter JR, Neuteboom ST, Wancewicz EV, Monia BP, Downing JR, Murre C | title = Oncogenic homeodomain transcription factor E2A-Pbx1 activates a novel WNT gene in pre-B acute lymphoblastoid leukemia | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 96 | issue = 20 | pages = 11464–9 | date = Sep 1999 | pmid = 10500199 | pmc = 18056 | doi = 10.1073/pnas.96.20.11464 }}
* {{cite journal | vauthors = McWhirter JR, Neuteboom ST, Wancewicz EV, Monia BP, Downing JR, Murre C | title = Oncogenic homeodomain transcription factor E2A-Pbx1 activates a novel WNT gene in pre-B acute lymphoblastoid leukemia | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 96 | issue = 20 | pages = 11464–9 | date = Sep 1999 | pmid = 10500199 | pmc = 18056 | doi = 10.1073/pnas.96.20.11464 }}
* {{cite journal | vauthors = Shanmugam K, Green NC, Rambaldi I, Saragovi HU, Featherstone MS | title = PBX and MEIS as non-DNA-binding partners in trimeric complexes with HOX proteins | journal = Molecular and Cellular Biology | volume = 19 | issue = 11 | pages = 7577–88 | date = Nov 1999 | pmid = 10523646 | pmc = 84774 | doi = }}
* {{cite journal | vauthors = Shanmugam K, Green NC, Rambaldi I, Saragovi HU, Featherstone MS | title = PBX and MEIS as non-DNA-binding partners in trimeric complexes with HOX proteins | journal = Molecular and Cellular Biology | volume = 19 | issue = 11 | pages = 7577–88 | date = Nov 1999 | pmid = 10523646 | pmc = 84774 | doi = 10.1128/MCB.19.11.7577}}
* {{cite journal | vauthors = Mikkola I, Bruun JA, Holm T, Johansen T | title = Superactivation of Pax6-mediated transactivation from paired domain-binding sites by dna-independent recruitment of different homeodomain proteins | journal = The Journal of Biological Chemistry | volume = 276 | issue = 6 | pages = 4109–18 | date = Feb 2001 | pmid = 11069920 | doi = 10.1074/jbc.M008882200 }}
* {{cite journal | vauthors = Mikkola I, Bruun JA, Holm T, Johansen T | title = Superactivation of Pax6-mediated transactivation from paired domain-binding sites by dna-independent recruitment of different homeodomain proteins | journal = The Journal of Biological Chemistry | volume = 276 | issue = 6 | pages = 4109–18 | date = Feb 2001 | pmid = 11069920 | doi = 10.1074/jbc.M008882200 }}
* {{cite journal | vauthors = Thameem F, Wolford JK, Bogardus C, Prochazka M | title = Analysis of PBX1 as a candidate gene for type 2 diabetes mellitus in Pima Indians | journal = Biochimica et Biophysica Acta | volume = 1518 | issue = 1-2 | pages = 215–20 | date = Mar 2001 | pmid = 11267683 | doi = 10.1016/S0167-4781(01)00189-0 }}
* {{cite journal | vauthors = Thameem F, Wolford JK, Bogardus C, Prochazka M | title = Analysis of PBX1 as a candidate gene for type 2 diabetes mellitus in Pima Indians | journal = Biochimica et Biophysica Acta | volume = 1518 | issue = 1–2 | pages = 215–20 | date = Mar 2001 | pmid = 11267683 | doi = 10.1016/S0167-4781(01)00189-0 | url = https://zenodo.org/record/1259885 }}
* {{cite journal | vauthors = Liu Y, MacDonald RJ, Swift GH | title = DNA binding and transcriptional activation by a PDX1.PBX1b.MEIS2b trimer and cooperation with a pancreas-specific basic helix-loop-helix complex | journal = The Journal of Biological Chemistry | volume = 276 | issue = 21 | pages = 17985–93 | date = May 2001 | pmid = 11279116 | doi = 10.1074/jbc.M100678200 }}
* {{cite journal | vauthors = Liu Y, MacDonald RJ, Swift GH | title = DNA binding and transcriptional activation by a PDX1.PBX1b.MEIS2b trimer and cooperation with a pancreas-specific basic helix-loop-helix complex | journal = The Journal of Biological Chemistry | volume = 276 | issue = 21 | pages = 17985–93 | date = May 2001 | pmid = 11279116 | doi = 10.1074/jbc.M100678200 }}
* {{cite journal | vauthors = Mal A, Sturniolo M, Schiltz RL, Ghosh MK, Harter ML | title = A role for histone deacetylase HDAC1 in modulating the transcriptional activity of MyoD: inhibition of the myogenic program | journal = The EMBO Journal | volume = 20 | issue = 7 | pages = 1739–53 | date = Apr 2001 | pmid = 11285237 | pmc = 145490 | doi = 10.1093/emboj/20.7.1739 }}
* {{cite journal | vauthors = Mal A, Sturniolo M, Schiltz RL, Ghosh MK, Harter ML | title = A role for histone deacetylase HDAC1 in modulating the transcriptional activity of MyoD: inhibition of the myogenic program | journal = The EMBO Journal | volume = 20 | issue = 7 | pages = 1739–53 | date = Apr 2001 | pmid = 11285237 | pmc = 145490 | doi = 10.1093/emboj/20.7.1739 }}

Revision as of 10:53, 1 July 2019

PBX1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPBX1, PBX homeobox 1, CAKUHED
External IDsOMIM: 176310; MGI: 97495; HomoloGene: 20574; GeneCards: PBX1; OMA:PBX1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

5087

18514

Ensembl

ENSG00000185630

ENSMUSG00000052534

UniProt

P40424

P41778

RefSeq (mRNA)

NM_001204961
NM_001204963
NM_002585
NM_001353130
NM_001353131

NM_001291508
NM_001291509
NM_008783
NM_183355

RefSeq (protein)

NP_001191890
NP_001191892
NP_002576
NP_001340059
NP_001340060

NP_001278437
NP_001278438
NP_032809
NP_899198

Location (UCSC)Chr 1: 164.56 – 164.9 MbChr 1: 167.95 – 168.26 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Pre-B-cell leukemia transcription factor 1 is a protein that in humans is encoded by the PBX1 gene.[5]

Interactions

PBX1 has been shown to interact with:

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000185630 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000052534 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: PBX1 Pre-B-cell leukemia homeobox 1".
  6. ^ Berthelsen J, Zappavigna V, Ferretti E, Mavilio F, Blasi F (Mar 1998). "The novel homeoprotein Prep1 modulates Pbx-Hox protein cooperativity". The EMBO Journal. 17 (5): 1434–45. doi:10.1093/emboj/17.5.1434. PMC 1170491. PMID 9482740.
  7. ^ Piper DE, Batchelor AH, Chang CP, Cleary ML, Wolberger C (Feb 1999). "Structure of a HoxB1-Pbx1 heterodimer bound to DNA: role of the hexapeptide and a fourth homeodomain helix in complex formation". Cell. 96 (4): 587–97. doi:10.1016/S0092-8674(00)80662-5. PMID 10052460.
  8. ^ Chang CP, Shen WF, Rozenfeld S, Lawrence HJ, Largman C, Cleary ML (Mar 1995). "Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins". Genes & Development. 9 (6): 663–74. doi:10.1101/gad.9.6.663. PMID 7729685.
  9. ^ Shen WF, Rozenfeld S, Kwong A, Köm ves LG, Lawrence HJ, Largman C (Apr 1999). "HOXA9 forms triple complexes with PBX2 and MEIS1 in myeloid cells". Molecular and Cellular Biology. 19 (4): 3051–61. doi:10.1128/MCB.19.4.3051. PMC 84099. PMID 10082572.
  10. ^ Shanmugam K, Green NC, Rambaldi I, Saragovi HU, Featherstone MS (Nov 1999). "PBX and MEIS as non-DNA-binding partners in trimeric complexes with HOX proteins". Molecular and Cellular Biology. 19 (11): 7577–88. doi:10.1128/MCB.19.11.7577. PMC 84774. PMID 10523646.
  11. ^ Jacobs Y, Schnabel CA, Cleary ML (Jul 1999). "Trimeric association of Hox and TALE homeodomain proteins mediates Hoxb2 hindbrain enhancer activity". Molecular and Cellular Biology. 19 (7): 5134–42. doi:10.1128/MCB.19.7.5134. PMC 84356. PMID 10373562.
  12. ^ Zubair M, Ishihara S, Oka S, Okumura K, Morohashi K (Jun 2006). "Two-step regulation of Ad4BP/SF-1 gene transcription during fetal adrenal development: initiation by a Hox-Pbx1-Prep1 complex and maintenance via autoregulation by Ad4BP/SF-1". Molecular and Cellular Biology. 26 (11): 4111–21. doi:10.1128/MCB.00222-06. PMC 1489093. PMID 16705164.

Further reading

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