ZNF300

ZNF300
Identifiers
Aliases	ZNF300, zinc finger protein 300
External IDs	OMIM: 612429; HomoloGene: 56531; GeneCards: ZNF300; OMA:ZNF300 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	150,904,983 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; ventricular zone; ; Achilles tendon; ; gonad; ; left ovary; ; right ovary; ; testicle; ; metanephros; ; left lobe of thyroid gland; ; body of pancreas;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA-binding transcription factor activity; DNA binding; protein binding; metal ion binding; nucleic acid binding; DNA-binding transcription activator activity, RNA polymerase II-specific; sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	intracellular anatomical structure; nucleus; nucleolus;
Biological process	regulation of transcription, DNA-templated; transcription, DNA-templated; transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	91975
	n/a
	ENSG00000145908
	n/a
	Q96RE9
	n/a
	NM_001172831; NM_001172832; NM_052860
	n/a
	NP_001166302; NP_001166303; NP_443092
	n/a
	Wikidata
View/Edit Human

Zinc finger protein 300 is a protein that in humans is encoded by the ZNF300 gene.^[3]^[4] The protein encoded by this gene is a C2H2-type zinc finger DNA binding protein and a likely transcription factor.

It is antisense to the human gene, C16orf71, indicating possibility of regulated alternative expression.^[5]

Clinical relevance

It is associated with Crohn's disease.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000145908 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Gou D, Wang J, Gao L, Sun Y, Peng X, Huang J, et al. (January 2004). "Identification and functional analysis of a novel human KRAB/C2H2 zinc finger gene ZNF300". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1676 (2): 203–209. doi:10.1016/j.bbaexp.2003.11.011. PMID 14746915.
^ "Entrez Gene: zinc finger protein 300".
^ Danielle Thierry-Mieg, Jean Thierry-Mieg. "AceView: Gene:C16orf71, a comprehensive annotation of human, mouse and worm genes with mRNAs or ESTsAceView". www.ncbi.nlm.nih.gov. Retrieved 2017-05-20.
^ Prescott NJ, Dominy KM, Kubo M, Lewis CM, Fisher SA, Redon R, et al. (May 2010). "Independent and population-specific association of risk variants at the IRGM locus with Crohn's disease". Human Molecular Genetics. 19 (9): 1828–1839. doi:10.1093/hmg/ddq041. PMC 2850616. PMID 20106866.

Feng T, Zhu X (September 2010). "Genome-wide searching of rare genetic variants in WTCCC data". Human Genetics. 128 (3): 269–280. doi:10.1007/s00439-010-0849-9. PMC 2922446. PMID 20549515.
Qiu H, Xue L, Gao L, Shao H, Wang D, Guo M, et al. (2008). "Identification of the DNA binding element of the human ZNF300 protein". Cellular & Molecular Biology Letters. 13 (3): 391–403. doi:10.2478/s11658-008-0005-x. PMC 6275660. PMID 18350257.
Xu JH, Wang T, Wang XG, Wu XP, Zhao ZZ, Zhu CG, et al. (December 2010). "PU.1 can regulate the ZNF300 promoter in APL-derived promyelocytes HL-60". Leukemia Research. 34 (12): 1636–1646. doi:10.1016/j.leukres.2010.04.009. PMID 20471086.
Xue L, Qiu H, Ma J, Guo M, Li W (December 2010). "ZNF300, a recently identified human transcription factor, activates the human IL-2Rβ promoter through the overlapping ZNF300/EGR1 binding site". Cellular & Molecular Biology Letters. 15 (4): 530–540. doi:10.2478/s11658-010-0025-1. PMC 6275642. PMID 20585888.
Oh JH, Yang JO, Hahn Y, Kim MR, Byun SS, Jeon YJ, et al. (December 2005). "Transcriptome analysis of human gastric cancer". Mammalian Genome. 16 (12): 942–954. doi:10.1007/s00335-005-0075-2. PMID 16341674. S2CID 69278.
Cao Y, Li JX, Ji CN, Xu XW, Wu M (August 2007). "Molecular cloning and characterization of a novel splice variant of human ZNF300 gene, which expressed highly in testis". DNA Sequence. 18 (4): 312–315. doi:10.1080/10425170701243393. PMID 17541838. S2CID 12932222.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, et al. (January 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Burton PR, Clayton DG, Cardon LR, Craddock N, Deloukas P, Duncanson A, et al. (Wellcome Trust Case Control Consortium) (June 2007). "Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls". Nature. 447 (7145): 661–678. Bibcode:2007Natur.447..661B. doi:10.1038/nature05911. PMC 2719288. PMID 17554300.

This article on a gene on human chromosome 5 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000145908 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid14746915-3] Gou D, Wang J, Gao L, Sun Y, Peng X, Huang J, et al. (January 2004). "Identification and functional analysis of a novel human KRAB/C2H2 zinc finger gene ZNF300". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1676 (2): 203–209. doi:10.1016/j.bbaexp.2003.11.011. PMID 14746915.

[entrez-4] "Entrez Gene: zinc finger protein 300".

[5] Danielle Thierry-Mieg, Jean Thierry-Mieg. "AceView: Gene:C16orf71, a comprehensive annotation of human, mouse and worm genes with mRNAs or ESTsAceView". www.ncbi.nlm.nih.gov. Retrieved 2017-05-20.

[pmid20106866-6] Prescott NJ, Dominy KM, Kubo M, Lewis CM, Fisher SA, Redon R, et al. (May 2010). "Independent and population-specific association of risk variants at the IRGM locus with Crohn's disease". Human Molecular Genetics. 19 (9): 1828–1839. doi:10.1093/hmg/ddq041. PMC 2850616. PMID 20106866.

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[2]

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[6]

Clinical relevance

References

Further reading