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Hepatocyte nuclear factor 4 gamma

From Wikipedia, the free encyclopedia

HNF4G
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesHNF4G, NR2A2, NR2A3, Hepatocyte nuclear factor 4 gamma
External IDsOMIM: 605966; MGI: 1353604; HomoloGene: 37886; GeneCards: HNF4G; OMA:HNF4G - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004133
NM_001330561

NM_013920
NM_001395870

RefSeq (protein)

NP_001317490
NP_004124

NP_038948
NP_001382799

Location (UCSC)Chr 8: 75.41 – 75.57 MbChr 3: 3.57 – 3.72 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Hepatocyte nuclear factor 4 gamma (HNF4G) also known as NR2A2 (nuclear receptor subfamily 2, group A, member 2) is a nuclear receptor that in humans is encoded by the HNF4G gene.[5][6][7]

Function

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HNF4G is a transcription factor that has been shown to play a significant role in intestinal epithelial cell differentiation and function. Research using integrative multi-omics analysis of intestinal organoid differentiation has revealed that HNF4G acts as a master regulator of gene regulation in differentiation towards the enterocyte lineage.[8] The study demonstrated widespread binding to promoters and enhancers that are activated in enterocytes, and that the loss of Hnf4g results in a partial loss of enterocyte differentiation, indicating its importance in maintaining the enterocyte lineage.

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000164749Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000017688Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: HNF4G hepatocyte nuclear factor 4, gamma".
  6. ^ Drewes T, Senkel S, Holewa B, Ryffel GU (March 1996). "Human hepatocyte nuclear factor 4 isoforms are encoded by distinct and differentially expressed genes". Molecular and Cellular Biology. 16 (3): 925–931. doi:10.1128/mcb.16.3.925. PMC 231074. PMID 8622695.
  7. ^ Wisely GB, Miller AB, Davis RG, Thornquest AD, Johnson R, Spitzer T, et al. (September 2002). "Hepatocyte nuclear factor 4 is a transcription factor that constitutively binds fatty acids". Structure. 10 (9): 1225–1234. doi:10.1016/S0969-2126(02)00829-8. PMID 12220494.
  8. ^ Lindeboom RG, van Voorthuijsen L, Oost KC, Rodríguez-Colman MJ, Luna-Velez MV, Furlan C, et al. (June 2018). "Integrative multi-omics analysis of intestinal organoid differentiation". Molecular Systems Biology. 14 (6): e8227. doi:10.15252/msb.20188227. PMC 6018986. PMID 29945941.

Further reading

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  • Plengvidhya N, Antonellis A, Wogan LT, Poleev A, Borgschulze M, Warram JH, et al. (October 1999). "Hepatocyte nuclear factor-4gamma: cDNA sequence, gene organization, and mutation screening in early-onset autosomal-dominant type 2 diabetes". Diabetes. 48 (10): 2099–2102. doi:10.2337/diabetes.48.10.2099. PMID 10512380.
  • Ozeki T, Takahashi Y, Nakayama K, Funayama M, Nagashima K, Kodama T, et al. (January 2003). "Hepatocyte nuclear factor-4 alpha/gamma and hepatocyte nuclear factor-1 alpha as causal factors of interindividual difference in the expression of human dihydrodiol dehydrogenase 4 mRNA in human livers". Pharmacogenetics. 13 (1): 49–53. doi:10.1097/00008571-200301000-00007. PMID 12544512.
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